Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats

Robert B. Trelease, Gary C Sieck, Jeremy D. Marks, Ronald M. Harper

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The effects of transient blood pressure elevation, induced by intravenous injection of phenylephrine, were studied in drug-free, unrestrained cats during sleep and waking. Transient hypertension evoked an increase in respiratory cycle duration (Ttot), an effect which was most prominent during quiet sleep. Transient hypertension evoked no overall change in inspiratory duration (Tdi) during any sleep-waking state, although reduction of diaphragmatic EMG amplitude was observed. Thus, the ratio of diaphragmatic activity time to total respiratory cycle duration ( Tdi Ttot) was decreased following blood pressure elevation. Apneic episodes occasionally occurred, and these occurrences were more frequent during sleep states. Apneas induced during quiet sleep were often associated with transient or sustained arousal.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalExperimental Neurology
Volume90
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Sleep
Cats
Hypertension
Blood Pressure
Phenylephrine
Apnea
Arousal
Intravenous Injections
Inhibition (Psychology)
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats. / Trelease, Robert B.; Sieck, Gary C; Marks, Jeremy D.; Harper, Ronald M.

In: Experimental Neurology, Vol. 90, No. 1, 1985, p. 173-186.

Research output: Contribution to journalArticle

Trelease, Robert B. ; Sieck, Gary C ; Marks, Jeremy D. ; Harper, Ronald M. / Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats. In: Experimental Neurology. 1985 ; Vol. 90, No. 1. pp. 173-186.
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