Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats

Robert B. Trelease; Gary C. Sieck; Jeremy D. Marks; Ronald M. Harper

doi:10.1016/0014-4886(85)90050-0

Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats

Robert B. Trelease, Gary C. Sieck, Jeremy D. Marks, Ronald M. Harper

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

The effects of transient blood pressure elevation, induced by intravenous injection of phenylephrine, were studied in drug-free, unrestrained cats during sleep and waking. Transient hypertension evoked an increase in respiratory cycle duration (T_tot), an effect which was most prominent during quiet sleep. Transient hypertension evoked no overall change in inspiratory duration (T_di) during any sleep-waking state, although reduction of diaphragmatic EMG amplitude was observed. Thus, the ratio of diaphragmatic activity time to total respiratory cycle duration ( T_di T_tot) was decreased following blood pressure elevation. Apneic episodes occasionally occurred, and these occurrences were more frequent during sleep states. Apneas induced during quiet sleep were often associated with transient or sustained arousal.

Original language	English (US)
Pages (from-to)	173-186
Number of pages	14
Journal	Experimental Neurology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(85)90050-0
State	Published - Oct 1985

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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@article{0c2fee67ae16470596f17ff0116ffe95,

title = "Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats",

abstract = "The effects of transient blood pressure elevation, induced by intravenous injection of phenylephrine, were studied in drug-free, unrestrained cats during sleep and waking. Transient hypertension evoked an increase in respiratory cycle duration (Ttot), an effect which was most prominent during quiet sleep. Transient hypertension evoked no overall change in inspiratory duration (Tdi) during any sleep-waking state, although reduction of diaphragmatic EMG amplitude was observed. Thus, the ratio of diaphragmatic activity time to total respiratory cycle duration ( Tdi Ttot) was decreased following blood pressure elevation. Apneic episodes occasionally occurred, and these occurrences were more frequent during sleep states. Apneas induced during quiet sleep were often associated with transient or sustained arousal.",

author = "Trelease, {Robert B.} and Sieck, {Gary C.} and Marks, {Jeremy D.} and Harper, {Ronald M.}",

note = "Funding Information: Abbreviations. AW-quiet wakefulness, QS-quiet sleep, REM-rapid eye-movement, MAP-mean arterial pressure, BP-blood pressure, T,,-interval between onsets of diaphragmatic activity, Tdi-duration of diaphragmatic activity. {\textquoteright} This study was supported by grants HL 22418-06 and HL 29999-03 from the National Heart Lung and Blood Institute and by 678-1G2 from the American Heart Association, Greater Los Angeles Affiliate. The authors thank David Taube for expert technical assistance. Please address correspondence to Robert B. Trelease, Ph.D., UCLA Sleep Disorders Clinic, Reed NRC, CHS, Los Angeles, CA 90024.",

year = "1985",

month = oct,

doi = "10.1016/0014-4886(85)90050-0",

language = "English (US)",

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pages = "173--186",

journal = "Experimental Neurology",

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T1 - Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats

AU - Trelease, Robert B.

AU - Sieck, Gary C.

AU - Marks, Jeremy D.

AU - Harper, Ronald M.

N1 - Funding Information: Abbreviations. AW-quiet wakefulness, QS-quiet sleep, REM-rapid eye-movement, MAP-mean arterial pressure, BP-blood pressure, T,,-interval between onsets of diaphragmatic activity, Tdi-duration of diaphragmatic activity. ’ This study was supported by grants HL 22418-06 and HL 29999-03 from the National Heart Lung and Blood Institute and by 678-1G2 from the American Heart Association, Greater Los Angeles Affiliate. The authors thank David Taube for expert technical assistance. Please address correspondence to Robert B. Trelease, Ph.D., UCLA Sleep Disorders Clinic, Reed NRC, CHS, Los Angeles, CA 90024.

PY - 1985/10

Y1 - 1985/10

N2 - The effects of transient blood pressure elevation, induced by intravenous injection of phenylephrine, were studied in drug-free, unrestrained cats during sleep and waking. Transient hypertension evoked an increase in respiratory cycle duration (Ttot), an effect which was most prominent during quiet sleep. Transient hypertension evoked no overall change in inspiratory duration (Tdi) during any sleep-waking state, although reduction of diaphragmatic EMG amplitude was observed. Thus, the ratio of diaphragmatic activity time to total respiratory cycle duration ( Tdi Ttot) was decreased following blood pressure elevation. Apneic episodes occasionally occurred, and these occurrences were more frequent during sleep states. Apneas induced during quiet sleep were often associated with transient or sustained arousal.

AB - The effects of transient blood pressure elevation, induced by intravenous injection of phenylephrine, were studied in drug-free, unrestrained cats during sleep and waking. Transient hypertension evoked an increase in respiratory cycle duration (Ttot), an effect which was most prominent during quiet sleep. Transient hypertension evoked no overall change in inspiratory duration (Tdi) during any sleep-waking state, although reduction of diaphragmatic EMG amplitude was observed. Thus, the ratio of diaphragmatic activity time to total respiratory cycle duration ( Tdi Ttot) was decreased following blood pressure elevation. Apneic episodes occasionally occurred, and these occurrences were more frequent during sleep states. Apneas induced during quiet sleep were often associated with transient or sustained arousal.

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JO - Experimental Neurology

JF - Experimental Neurology

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ER -

Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats

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