Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state

Jacqueline K. Limberg, Barbara J. Morgan, William G. Schrage, Jerome A. Dempsey

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In patients with hypertension, volitional slowing of the respiratory rate has been purported to reduce arterial pressure via withdrawal of sympathetic tone. We examined the effects of paced breathing at 7, 14, and 21 breaths/min, with reciprocal changes in tidal volume, on muscle sympathetic nerve activity, forearm blood flow, forearm vascular conductance, and blood pressure in 21 men and women, 8 of whom had modest elevations in systemic arterial pressure. These alterations in breathing frequency and volume did not affect steady-state levels of sympathetic activity, blood flow, vascular conductance, or blood pressure (all P >0.05), even though they had the expected effect on sympathetic activity within breaths (i.e., increased modulation during low-frequency/high-tidal volume breathing) (P <0.001). These findings were consistent across subjects with widely varied baseline levels of sympathetic activity (4-fold), mean arterial pressure (78-110 mmHg), and vascular conductance (15-fold), and those who became hypocapnic during paced breathing vs. those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume304
Issue number12
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Blood Vessels
Respiration
Arterial Pressure
Muscles
Tidal Volume
Forearm
Blood Pressure
Respiratory Rate
Hypertension

Keywords

  • Blood pressure
  • Hypertension
  • Respiration

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state. / Limberg, Jacqueline K.; Morgan, Barbara J.; Schrage, William G.; Dempsey, Jerome A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 304, No. 12, 2013.

Research output: Contribution to journalArticle

Limberg, Jacqueline K. ; Morgan, Barbara J. ; Schrage, William G. ; Dempsey, Jerome A. / Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state. In: American Journal of Physiology - Heart and Circulatory Physiology. 2013 ; Vol. 304, No. 12.
@article{ac91a4dd831848a19a2832766952ee12,
title = "Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state",
abstract = "In patients with hypertension, volitional slowing of the respiratory rate has been purported to reduce arterial pressure via withdrawal of sympathetic tone. We examined the effects of paced breathing at 7, 14, and 21 breaths/min, with reciprocal changes in tidal volume, on muscle sympathetic nerve activity, forearm blood flow, forearm vascular conductance, and blood pressure in 21 men and women, 8 of whom had modest elevations in systemic arterial pressure. These alterations in breathing frequency and volume did not affect steady-state levels of sympathetic activity, blood flow, vascular conductance, or blood pressure (all P >0.05), even though they had the expected effect on sympathetic activity within breaths (i.e., increased modulation during low-frequency/high-tidal volume breathing) (P <0.001). These findings were consistent across subjects with widely varied baseline levels of sympathetic activity (4-fold), mean arterial pressure (78-110 mmHg), and vascular conductance (15-fold), and those who became hypocapnic during paced breathing vs. those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow.",
keywords = "Blood pressure, Hypertension, Respiration",
author = "Limberg, {Jacqueline K.} and Morgan, {Barbara J.} and Schrage, {William G.} and Dempsey, {Jerome A.}",
year = "2013",
doi = "10.1152/ajpheart.00112.2013",
language = "English (US)",
volume = "304",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "12",

}

TY - JOUR

T1 - Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state

AU - Limberg, Jacqueline K.

AU - Morgan, Barbara J.

AU - Schrage, William G.

AU - Dempsey, Jerome A.

PY - 2013

Y1 - 2013

N2 - In patients with hypertension, volitional slowing of the respiratory rate has been purported to reduce arterial pressure via withdrawal of sympathetic tone. We examined the effects of paced breathing at 7, 14, and 21 breaths/min, with reciprocal changes in tidal volume, on muscle sympathetic nerve activity, forearm blood flow, forearm vascular conductance, and blood pressure in 21 men and women, 8 of whom had modest elevations in systemic arterial pressure. These alterations in breathing frequency and volume did not affect steady-state levels of sympathetic activity, blood flow, vascular conductance, or blood pressure (all P >0.05), even though they had the expected effect on sympathetic activity within breaths (i.e., increased modulation during low-frequency/high-tidal volume breathing) (P <0.001). These findings were consistent across subjects with widely varied baseline levels of sympathetic activity (4-fold), mean arterial pressure (78-110 mmHg), and vascular conductance (15-fold), and those who became hypocapnic during paced breathing vs. those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow.

AB - In patients with hypertension, volitional slowing of the respiratory rate has been purported to reduce arterial pressure via withdrawal of sympathetic tone. We examined the effects of paced breathing at 7, 14, and 21 breaths/min, with reciprocal changes in tidal volume, on muscle sympathetic nerve activity, forearm blood flow, forearm vascular conductance, and blood pressure in 21 men and women, 8 of whom had modest elevations in systemic arterial pressure. These alterations in breathing frequency and volume did not affect steady-state levels of sympathetic activity, blood flow, vascular conductance, or blood pressure (all P >0.05), even though they had the expected effect on sympathetic activity within breaths (i.e., increased modulation during low-frequency/high-tidal volume breathing) (P <0.001). These findings were consistent across subjects with widely varied baseline levels of sympathetic activity (4-fold), mean arterial pressure (78-110 mmHg), and vascular conductance (15-fold), and those who became hypocapnic during paced breathing vs. those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow.

KW - Blood pressure

KW - Hypertension

KW - Respiration

UR - http://www.scopus.com/inward/record.url?scp=84879143115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879143115&partnerID=8YFLogxK

U2 - 10.1152/ajpheart.00112.2013

DO - 10.1152/ajpheart.00112.2013

M3 - Article

C2 - 23585141

AN - SCOPUS:84879143115

VL - 304

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 12

ER -