Respiratory effects of cyclic AMP following injection into the nucleus tractus solitarius of rats

R. A. Barraco, E. P. Schoener, P. M. Polasek, L. L. Simpson, C. J. Janusz, M. Parizon

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Rats were anesthetized with urethane and a limited occipital craniotomy was performed to expose the caudal medulla in the region of the obex. Injections were made into sites in the brainstem of spontaneously-breathing rats through glass micropipettes. Tidal volume, respiratory frequency, minute volume, blood pressure and heart rate were recorded before and after the administration of 8-bromoadenosine 3',5'-cyclic monophosphate (Br-cAMP), an analog of cyclic AMP. Injections of Br-cAMP into the ventromedial portion of the caudal nucleus tractus solitarius (NTS) produced dose-related decreases in pulmonary ventilation due to effects on both respiratory frequency, as well as minute volume. In larger doses, Br-cAMP produced periodic apnea and irregular breathing. The respiratory depression was accompanied by transient hypotension and bradycardia. The data indicate that cyclic AMP may function as a second messenger in respiratory control regions in the brainstem.

Original languageEnglish (US)
Pages (from-to)1285-1294
Number of pages10
JournalNeuropharmacology
Volume27
Issue number12
DOIs
StatePublished - Dec 1988

Keywords

  • cyclic AMP
  • nucleus tractus solitarius
  • respiratory control
  • respiratory rhythm
  • second messenger

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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