Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation

A case report

M. J. Mazur, A. C. Lowney, J. Prigoff, R. L. Heilman, Harini M Chakkera, A. Moss, D. Mulligan, Kunam Sudhakar Reddy, K. Hamawi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.

Original languageEnglish (US)
Pages (from-to)3296-3298
Number of pages3
JournalTransplantation Proceedings
Volume43
Issue number9
DOIs
StatePublished - Nov 2011

Fingerprint

Necrobiosis Lipoidica
Kidney Transplantation
Pancreas
Pancreas Transplantation
Immunosuppressive Agents
Immunosuppression
Diabetes Mellitus
Skin
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation : A case report. / Mazur, M. J.; Lowney, A. C.; Prigoff, J.; Heilman, R. L.; Chakkera, Harini M; Moss, A.; Mulligan, D.; Reddy, Kunam Sudhakar; Hamawi, K.

In: Transplantation Proceedings, Vol. 43, No. 9, 11.2011, p. 3296-3298.

Research output: Contribution to journalArticle

@article{ac77af2279be4651b61f252e061b7dd6,
title = "Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: A case report",
abstract = "Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.",
author = "Mazur, {M. J.} and Lowney, {A. C.} and J. Prigoff and Heilman, {R. L.} and Chakkera, {Harini M} and A. Moss and D. Mulligan and Reddy, {Kunam Sudhakar} and K. Hamawi",
year = "2011",
month = "11",
doi = "10.1016/j.transproceed.2011.10.005",
language = "English (US)",
volume = "43",
pages = "3296--3298",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "9",

}

TY - JOUR

T1 - Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation

T2 - A case report

AU - Mazur, M. J.

AU - Lowney, A. C.

AU - Prigoff, J.

AU - Heilman, R. L.

AU - Chakkera, Harini M

AU - Moss, A.

AU - Mulligan, D.

AU - Reddy, Kunam Sudhakar

AU - Hamawi, K.

PY - 2011/11

Y1 - 2011/11

N2 - Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.

AB - Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.

UR - http://www.scopus.com/inward/record.url?scp=81455132411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81455132411&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2011.10.005

DO - 10.1016/j.transproceed.2011.10.005

M3 - Article

VL - 43

SP - 3296

EP - 3298

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 9

ER -