Resistance to Peloruside a and Laulimalide: Functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding

Medicine & Life Sciences

• laulimalide 100%
• peloruside A 66%
• Tubulin 52%
• Mutation 27%
• Pharmaceutical Preparations 20%
• Polymerization 11%
• Microtubules 10%
• MutS Proteins 8%
• Binding Sites 8%
• Cell Line 6%
• p53 Genes 5%
• Paclitaxel 5%
• Neoplasms 5%
• Ovarian Neoplasms 4%
• Genes 4%
• Clone Cells 4%
• Cell Cycle 4%
• Amino Acids 3%
• Cell Proliferation 3%
• Phenotype 3%

Chemical Compounds

• Peloruside A 90%
• Mutation 41%
• Resistance 30%
• Polymerization Reaction 9%
• Acid 2%