TY - JOUR
T1 - Resident vascular progenitor cells-diverse origins, phenotype, and function
AU - Psaltis, Peter J.
AU - Harbuzariu, Adriana
AU - Delacroix, Sinny
AU - Holroyd, Eric W.
AU - Simari, Robert D.
N1 - Funding Information:
Acknowledgements This work was supported by grant funding from the National Institutes of Health (HL75566). Dr Psaltis receives post-doctoral research funding from the National Health and Medical Research Council of Australia and the Royal Australasian College of Physicians. The authors have no conflicts to disclose.
PY - 2011/4
Y1 - 2011/4
N2 - The fundamental contributions that blood vessels make toward organogenesis and tissue homeostasis are reflected by the considerable ramifications that loss of vascular wall integrity has on pre- and postnatal health. During both neovascularization and vessel wall remodeling after insult, the dynamic nature of vascular cell growth and replacement vitiates traditional impressions that blood vessels contain predominantly mature, terminally differentiated cell populations. Recent discoveries have verified the presence of diverse stem/progenitor cells for both vascular and non-vascular progeny within the mural layers of the vasculature. During embryogenesis, this encompasses the emergence of definitive hematopoietic stem cells and multipotent mesoangioblasts from the developing dorsal aorta. Ancestral cells have also been identified and isolated from mature, adult blood vessels, showing variable capacity for endothelial, smooth muscle, and mesenchymal differentiation. At present, the characterization of these different vascular wall progenitors remains somewhat rudimentary, but there is evidence for their constitutive residence within organized compartments in the vessel wall, most compellingly in the tunica adventitia. This review overviews the spectrum of resident stem/progenitor cells that have been documented in macro- and micro-vessels during developmental and adult life and considers the implications for a local, vascular wall stem cell niche(s) in the pathogenesis and treatment of cardiovascular and other diseases.
AB - The fundamental contributions that blood vessels make toward organogenesis and tissue homeostasis are reflected by the considerable ramifications that loss of vascular wall integrity has on pre- and postnatal health. During both neovascularization and vessel wall remodeling after insult, the dynamic nature of vascular cell growth and replacement vitiates traditional impressions that blood vessels contain predominantly mature, terminally differentiated cell populations. Recent discoveries have verified the presence of diverse stem/progenitor cells for both vascular and non-vascular progeny within the mural layers of the vasculature. During embryogenesis, this encompasses the emergence of definitive hematopoietic stem cells and multipotent mesoangioblasts from the developing dorsal aorta. Ancestral cells have also been identified and isolated from mature, adult blood vessels, showing variable capacity for endothelial, smooth muscle, and mesenchymal differentiation. At present, the characterization of these different vascular wall progenitors remains somewhat rudimentary, but there is evidence for their constitutive residence within organized compartments in the vessel wall, most compellingly in the tunica adventitia. This review overviews the spectrum of resident stem/progenitor cells that have been documented in macro- and micro-vessels during developmental and adult life and considers the implications for a local, vascular wall stem cell niche(s) in the pathogenesis and treatment of cardiovascular and other diseases.
KW - Angiogenesis
KW - Endothelial progenitor cells
KW - Hematopoietic stem cells
KW - Mesenchymal stem cells
KW - Smooth muscle progenitor cells
KW - Vascular progenitor cells
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U2 - 10.1007/s12265-010-9248-9
DO - 10.1007/s12265-010-9248-9
M3 - Review article
C2 - 21116882
AN - SCOPUS:79956368558
SN - 1937-5387
VL - 4
SP - 161
EP - 176
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 2
ER -