Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop

Sana M. Al-Khatib, Emelia J. Benjamin, Alfred E. Buxton, Hugh Calkins, Mina K. Chung, Anne B. Curtis, Patrice Desvigne-Nickens, Pierre Jais, Douglas L. Packer, Jonathan P. Piccini, Yves Rosenberg, Andrea M. Russo, Paul J. Wang, Lawton S. Cooper, Alan S. Go, Sana M. Al-Khatib, Emelia J. Benjamin, Alfred E. Buxton, Hugh Calkins, Mina K. ChungAnne B. Curtis, Patrice Desvigne-Nickens, Pierre Jais, Douglas L. Packer, Jonathan P. Piccini, Yves Rosenberg, Andrea M. Russo, Paul J. Wang, Lawton S. Cooper, Alan S. Go

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Catheter ablation has brought major advances in the management of patients with atrial fibrillation (AF). As evidenced by multiple randomized trials, AF catheter ablation can reduce the risk of recurrent AF and improve quality of life. In some studies, AF ablation significantly reduced cardiovascular hospitalizations. Despite the existing data on AF catheter ablation, numerous knowledge gaps remain concerning this intervention. This report is based on a recent virtual workshop convened by the National Heart, Lung, and Blood Institute to identify key research opportunities in AF ablation. We outline knowledge gaps related to emerging technologies, the relationship between cardiac structure and function and the success of AF ablation in patient subgroups in whom clinical benefit from ablation varies, and potential platforms to advance clinical research in this area. This report also considers the potential value and challenges of a sham ablation randomized trial. Prioritized research opportunities are identified and highlighted to empower relevant stakeholders to collaborate in designing and conducting effective, cost-efficient, and transformative research to optimize the use and outcomes of AF ablation.

Original languageEnglish (US)
Pages (from-to)482-492
Number of pages11
JournalCirculation
DOIs
StatePublished - Feb 11 2020

Keywords

  • atrial fibrillation
  • catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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