Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function

Nina Jones, Daniel Voskas, Zubin Master, Renu Sarao, Jamie Jones, Daniel J. Dumont

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Disruption of the signaling pathways mediated by the receptor tyrosine kinase Tek/Tie2 has shown that this receptor plays a pivotal role in vascularization of the developing embryo. In this report, we have utilized the tetracycline-responsive binary transgenic system to overcome the early lethal cardiovascular defects associated with the tekΔsp null allele in order to investigate the role of Tek in later stages of vessel growth. We show for the first time in vivo that synchronized loss of tek expression correlates with rapid endothelial cell apoptosis in hemorrhagic regions of the embryo, demonstrating an ongoing requirement for Tek-mediated signal transduction in vascular maintenance.

Original languageEnglish (US)
Pages (from-to)438-445
Number of pages8
JournalEMBO Reports
Volume2
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function'. Together they form a unique fingerprint.

  • Cite this