Republished: Pathogenesis and diagnosis of myocarditis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Acute myocarditis is an inflammatory disease of the heart muscle that may progress to dilated cardiomyopathy and chronic heart failure. A number of factors including the sex hormone testosterone, components of innate immunity, and profibrotic cytokines have been identified in animal models as important pathogenic mechanisms that increase inflammation and susceptibility to chronic dilated cardiomyopathy. The clinical presentation of acute myocarditis is non-specific and mimics more common causes of heart failure and arrhythmias. Suspected myocarditis is currently confirmed using advanced noninvasive imaging and histopathologic examination of heart tissue. However, the diverse presentations of myocarditis and the lack of widely available, safe, and accurate noninvasive diagnostic tests remain major obstacles to early diagnosis and population based research. Recent advances in the understanding of disease pathogenesis described in this review should lead to more accurate diagnostic algorithms and non-invasive tests.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalPostgraduate Medical Journal
Volume88
Issue number1043
DOIs
StatePublished - Sep 2012

Fingerprint

Myocarditis
Dilated Cardiomyopathy
Heart Failure
Gonadal Steroid Hormones
Routine Diagnostic Tests
Innate Immunity
Testosterone
Cardiac Arrhythmias
Early Diagnosis
Myocardium
Animal Models
Cytokines
Inflammation
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Republished : Pathogenesis and diagnosis of myocarditis. / Elamm, Chantal; Fairweather, DeLisa; Cooper, Leslie T Jr.

In: Postgraduate Medical Journal, Vol. 88, No. 1043, 09.2012, p. 539-544.

Research output: Contribution to journalArticle

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