Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study

Olivier Brouckaert; Anja Rudolph; Annouschka Laenen; Renske Keeman; Manjeet K. Bolla; Qin Wang; Adelheid Soubry; Hans Wildiers; Irene L. Andrulis; Volker Arndt; Matthias W. Beckmann; Javier Benitez; Carl Blomqvist; Stig E. Bojesen; Hiltrud Brauch; Paul Brennan; Hermann Brenner; Georgia Chenevix-Trench; Ji Yeob Choi; Sten Cornelissen; Fergus J. Couch; Angela Cox; Simon S. Cross; Kamila Czene; Mikael Eriksson; Peter A. Fasching; Jonine Figueroa; Henrik Flyger; Graham G. Giles; Anna González-Neira; Pascal Guénel; Per Hall; Antoinette Hollestelle; John L. Hopper; Hidemi Ito; Michael Jones; Daehee Kang; Julia A. Knight; Veli Matti Kosma; Jingmei Li; Annika Lindblom; Jenna Lilyquist; Artitaya Lophatananon; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Keitaro Matsuo; Kenneth Muir; Heli Nevanlinna; Paolo Peterlongo; Katri Pylkäs; Suleeporn Saajrang; Caroline Seynaeve; Chen Yang Shen; Xiao Ou Shu; Melissa C. Southey; Anthony Swerdlow; Soo Hwang Teo; Rob A.E.M. Tollenaar; Thérèse Truong; Chiu chen Tseng; Alexandra J. van den Broek; Carolien H.M. van Deurzen; Robert Winqvist; Anna H. Wu; Cheng Har Yip; Jyh Cherng Yu; Wei Zheng; Roger L. Milne; Paul D.P. Pharoah; Douglas F. Easton; Marjanka K. Schmidt; Montserrat Garcia-Closas; Jenny Chang-Claude; Diether Lambrechts; Patrick Neven; kConFab

doi:10.1186/s13058-017-0909-3

Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study

Olivier Brouckaert, Anja Rudolph, Annouschka Laenen, Renske Keeman, Manjeet K. Bolla, Qin Wang, Adelheid Soubry, Hans Wildiers, Irene L. Andrulis, Volker Arndt, Matthias W. Beckmann, Javier Benitez, Carl Blomqvist, Stig E. Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Georgia Chenevix-Trench, Ji Yeob Choi, Sten CornelissenFergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Graham G. Giles, Anna González-Neira, Pascal Guénel, Per Hall, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Michael Jones, Daehee Kang, Julia A. Knight, Veli Matti Kosma, Jingmei Li, Annika Lindblom, Jenna Lilyquist, Artitaya Lophatananon, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Keitaro Matsuo, Kenneth Muir, Heli Nevanlinna, Paolo Peterlongo, Katri Pylkäs, Suleeporn Saajrang, Caroline Seynaeve, Chen Yang Shen, Xiao Ou Shu, Melissa C. Southey, Anthony Swerdlow, Soo Hwang Teo, Rob A.E.M. Tollenaar, Thérèse Truong, Chiu chen Tseng, Alexandra J. van den Broek, Carolien H.M. van Deurzen, Robert Winqvist, Anna H. Wu, Cheng Har Yip, Jyh Cherng Yu, Wei Zheng, Roger L. Milne, Paul D.P. Pharoah, Douglas F. Easton, Marjanka K. Schmidt, Montserrat Garcia-Closas, Jenny Chang-Claude, Diether Lambrechts, Patrick Neven, kConFab

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.

Original language	English (US)
Article number	119
Journal	Breast Cancer Research
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13058-017-0909-3
State	Published - Nov 7 2017

Keywords

Age at breast cancer diagnosis
Age at first full-time pregnancy
Age at menarche
Breast cancer subtype
Parity

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1186/s13058-017-0909-3

Cite this

Brouckaert, O., Rudolph, A., Laenen, A., Keeman, R., Bolla, M. K., Wang, Q., Soubry, A., Wildiers, H., Andrulis, I. L., Arndt, V., Beckmann, M. W., Benitez, J., Blomqvist, C., Bojesen, S. E., Brauch, H., Brennan, P., Brenner, H., Chenevix-Trench, G., Choi, J. Y., ... kConFab (2017). Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study. Breast Cancer Research, 19(1), Article 119. https://doi.org/10.1186/s13058-017-0909-3

Brouckaert, O, Rudolph, A, Laenen, A, Keeman, R, Bolla, MK, Wang, Q, Soubry, A, Wildiers, H, Andrulis, IL, Arndt, V, Beckmann, MW, Benitez, J, Blomqvist, C, Bojesen, SE, Brauch, H, Brennan, P, Brenner, H, Chenevix-Trench, G, Choi, JY, Cornelissen, S, Couch, FJ, Cox, A, Cross, SS, Czene, K, Eriksson, M, Fasching, PA, Figueroa, J, Flyger, H, Giles, GG, González-Neira, A, Guénel, P, Hall, P, Hollestelle, A, Hopper, JL, Ito, H, Jones, M, Kang, D, Knight, JA, Kosma, VM, Li, J, Lindblom, A, Lilyquist, J, Lophatananon, A, Mannermaa, A, Manoukian, S, Margolin, S, Matsuo, K, Muir, K, Nevanlinna, H, Peterlongo, P, Pylkäs, K, Saajrang, S, Seynaeve, C, Shen, CY, Shu, XO, Southey, MC, Swerdlow, A, Teo, SH, Tollenaar, RAEM, Truong, T, Tseng, CC, van den Broek, AJ, van Deurzen, CHM, Winqvist, R, Wu, AH, Yip, CH, Yu, JC, Zheng, W, Milne, RL, Pharoah, PDP, Easton, DF, Schmidt, MK, Garcia-Closas, M, Chang-Claude, J, Lambrechts, D, Neven, P & kConFab 2017, 'Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study', Breast Cancer Research, vol. 19, no. 1, 119. https://doi.org/10.1186/s13058-017-0909-3

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title = "Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study",

abstract = "Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.",

keywords = "Age at breast cancer diagnosis, Age at first full-time pregnancy, Age at menarche, Breast cancer subtype, Parity",

author = "Olivier Brouckaert and Anja Rudolph and Annouschka Laenen and Renske Keeman and Bolla, {Manjeet K.} and Qin Wang and Adelheid Soubry and Hans Wildiers and Andrulis, {Irene L.} and Volker Arndt and Beckmann, {Matthias W.} and Javier Benitez and Carl Blomqvist and Bojesen, {Stig E.} and Hiltrud Brauch and Paul Brennan and Hermann Brenner and Georgia Chenevix-Trench and Choi, {Ji Yeob} and Sten Cornelissen and Couch, {Fergus J.} and Angela Cox and Cross, {Simon S.} and Kamila Czene and Mikael Eriksson and Fasching, {Peter A.} and Jonine Figueroa and Henrik Flyger and Giles, {Graham G.} and Anna Gonz{\'a}lez-Neira and Pascal Gu{\'e}nel and Per Hall and Antoinette Hollestelle and Hopper, {John L.} and Hidemi Ito and Michael Jones and Daehee Kang and Knight, {Julia A.} and Kosma, {Veli Matti} and Jingmei Li and Annika Lindblom and Jenna Lilyquist and Artitaya Lophatananon and Arto Mannermaa and Siranoush Manoukian and Sara Margolin and Keitaro Matsuo and Kenneth Muir and Heli Nevanlinna and Paolo Peterlongo and Katri Pylk{\"a}s and Suleeporn Saajrang and Caroline Seynaeve and Shen, {Chen Yang} and Shu, {Xiao Ou} and Southey, {Melissa C.} and Anthony Swerdlow and Teo, {Soo Hwang} and Tollenaar, {Rob A.E.M.} and Th{\'e}r{\`e}se Truong and Tseng, {Chiu chen} and {van den Broek}, {Alexandra J.} and {van Deurzen}, {Carolien H.M.} and Robert Winqvist and Wu, {Anna H.} and Yip, {Cheng Har} and Yu, {Jyh Cherng} and Wei Zheng and Milne, {Roger L.} and Pharoah, {Paul D.P.} and Easton, {Douglas F.} and Schmidt, {Marjanka K.} and Montserrat Garcia-Closas and Jenny Chang-Claude and Diether Lambrechts and Patrick Neven and kConFab",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = nov,

day = "7",

doi = "10.1186/s13058-017-0909-3",

language = "English (US)",

volume = "19",

journal = "Breast Cancer Research",

issn = "1465-5411",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Reproductive profiles and risk of breast cancer subtypes

T2 - A multi-center case-only study

AU - Brouckaert, Olivier

AU - Rudolph, Anja

AU - Laenen, Annouschka

AU - Keeman, Renske

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Soubry, Adelheid

AU - Wildiers, Hans

AU - Andrulis, Irene L.

AU - Arndt, Volker

AU - Beckmann, Matthias W.

AU - Benitez, Javier

AU - Blomqvist, Carl

AU - Bojesen, Stig E.

AU - Brauch, Hiltrud

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Chenevix-Trench, Georgia

AU - Choi, Ji Yeob

AU - Cornelissen, Sten

AU - Couch, Fergus J.

AU - Cox, Angela

AU - Cross, Simon S.

AU - Czene, Kamila

AU - Eriksson, Mikael

AU - Fasching, Peter A.

AU - Figueroa, Jonine

AU - Flyger, Henrik

AU - Giles, Graham G.

AU - González-Neira, Anna

AU - Guénel, Pascal

AU - Hall, Per

AU - Hollestelle, Antoinette

AU - Hopper, John L.

AU - Ito, Hidemi

AU - Jones, Michael

AU - Kang, Daehee

AU - Knight, Julia A.

AU - Kosma, Veli Matti

AU - Li, Jingmei

AU - Lindblom, Annika

AU - Lilyquist, Jenna

AU - Lophatananon, Artitaya

AU - Mannermaa, Arto

AU - Manoukian, Siranoush

AU - Margolin, Sara

AU - Matsuo, Keitaro

AU - Muir, Kenneth

AU - Nevanlinna, Heli

AU - Peterlongo, Paolo

AU - Pylkäs, Katri

AU - Saajrang, Suleeporn

AU - Seynaeve, Caroline

AU - Shen, Chen Yang

AU - Shu, Xiao Ou

AU - Southey, Melissa C.

AU - Swerdlow, Anthony

AU - Teo, Soo Hwang

AU - Tollenaar, Rob A.E.M.

AU - Truong, Thérèse

AU - Tseng, Chiu chen

AU - van den Broek, Alexandra J.

AU - van Deurzen, Carolien H.M.

AU - Winqvist, Robert

AU - Wu, Anna H.

AU - Yip, Cheng Har

AU - Yu, Jyh Cherng

AU - Zheng, Wei

AU - Milne, Roger L.

AU - Pharoah, Paul D.P.

AU - Easton, Douglas F.

AU - Schmidt, Marjanka K.

AU - Garcia-Closas, Montserrat

AU - Chang-Claude, Jenny

AU - Lambrechts, Diether

AU - Neven, Patrick

AU - kConFab,

PY - 2017/11/7

Y1 - 2017/11/7

N2 - Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.

AB - Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.

KW - Age at breast cancer diagnosis

KW - Age at first full-time pregnancy

KW - Age at menarche

KW - Breast cancer subtype

KW - Parity

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UR - http://www.scopus.com/inward/citedby.url?scp=85033407313&partnerID=8YFLogxK

U2 - 10.1186/s13058-017-0909-3

DO - 10.1186/s13058-017-0909-3

M3 - Article

C2 - 29116004

AN - SCOPUS:85033407313

SN - 1465-5411

VL - 19

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 1

M1 - 119

ER -

Reproductive profiles and risk of breast cancer subtypes: A multi-center case-only study

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