Reproductive fitness advantage of BCR-ABL expressing leukemia cells

Arne Traulsen, Jorge M. Pacheco, David M Dingli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. We utilize a model of chronic myeloid leukemia (CML), to quantitate the fitness advantage conferred by expression of BCR- ABL in hematopoietic cells from in vivo patient data. We show that BCR- ABL expression provides a high fitness advantage, which explains why this single mutation drives the chronic phase of CML.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalCancer Letters
Volume294
Issue number1
DOIs
StatePublished - Aug 2010

Fingerprint

Genetic Fitness
Oncogenes
Leukemia
Leukemia, Myeloid, Chronic Phase
Neoplasms
Mutation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumor Suppressor Genes
Phenotype
Genes

Keywords

  • BCR-ABL
  • Cancer dynamics
  • Cancer evolution
  • Mutation fitness
  • Oncogenes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Reproductive fitness advantage of BCR-ABL expressing leukemia cells. / Traulsen, Arne; Pacheco, Jorge M.; Dingli, David M.

In: Cancer Letters, Vol. 294, No. 1, 08.2010, p. 43-48.

Research output: Contribution to journalArticle

Traulsen, Arne ; Pacheco, Jorge M. ; Dingli, David M. / Reproductive fitness advantage of BCR-ABL expressing leukemia cells. In: Cancer Letters. 2010 ; Vol. 294, No. 1. pp. 43-48.
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