TY - JOUR
T1 - Reproducibility of human kidney perfusion and volume determinations with electron beam computed tomography
AU - Lerman, Lilach O.
AU - Flickinger, Allen L.
AU - Sheedy, Patrick F.
AU - Turner, Stephen T.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996/4
Y1 - 1996/4
N2 - RATIONALE AND OBJECTIVES. Alterations in whole kidney, cortical, and medullary perfusion and volume play a pivotal role in various physiologic and pathophysiologic processes. Electron-beam computed tomography (EBCT) provides accurate measurements of these traits in animals, but their reproducibility in humans has not been established. METHODS. Perfusion, volume, and flow measurements were obtained by EBCT in eight healthy human volunteers under controlled conditions on two consecutive days. RESULTS. Mean values for whole kidney, cortical, and medullary perfusion and volume obtained with EBCT were similar in scan 1 and scan 2 (P > 0.1), and correlated highly. Coefficients of variation for the repeated measurements usually were less than 10%. Values obtained for renal regional perfusion and volume agreed with previously reported values. CONCLUSIONS. Electron-beam computed tomography estimates of single whole kidney, cortical, and medullary perfusions and volumes are highly reproducible in normal humans, and may be useful to advance understanding of renal involvement in human disease.
AB - RATIONALE AND OBJECTIVES. Alterations in whole kidney, cortical, and medullary perfusion and volume play a pivotal role in various physiologic and pathophysiologic processes. Electron-beam computed tomography (EBCT) provides accurate measurements of these traits in animals, but their reproducibility in humans has not been established. METHODS. Perfusion, volume, and flow measurements were obtained by EBCT in eight healthy human volunteers under controlled conditions on two consecutive days. RESULTS. Mean values for whole kidney, cortical, and medullary perfusion and volume obtained with EBCT were similar in scan 1 and scan 2 (P > 0.1), and correlated highly. Coefficients of variation for the repeated measurements usually were less than 10%. Values obtained for renal regional perfusion and volume agreed with previously reported values. CONCLUSIONS. Electron-beam computed tomography estimates of single whole kidney, cortical, and medullary perfusions and volumes are highly reproducible in normal humans, and may be useful to advance understanding of renal involvement in human disease.
KW - Renal circulation
KW - renal volume
KW - x-ray CT
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U2 - 10.1097/00004424-199604000-00004
DO - 10.1097/00004424-199604000-00004
M3 - Article
C2 - 8721959
AN - SCOPUS:0029969296
SN - 0020-9996
VL - 31
SP - 204
EP - 210
JO - Investigative Radiology
JF - Investigative Radiology
IS - 4
ER -