Reprint of "Cortical reorganization of language functioning following perinatal left MCA stroke" [Brain and Language 105 (2008) 99-111]

Jan-Mendelt Tillema, Anna W. Byars, Lisa M. Jacola, Mark B. Schapiro, Vince J. Schmithorst, Jerzy P. Szaflarski, Scott K. Holland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Functional MRI was used to determine differences in patterns of cortical activation between children who suffered perinatal left middle cerebral artery (MCA) stroke and healthy children performing a silent verb generation task. Methods: Ten children with prior perinatal left MCA stroke (age 6-16 years) and ten healthy age matched controls completed an executive language activation task. fMRI scans were acquired on a 3 T scanner using T2* weighted gradient echo, echo-planar imaging (EPI) sequence. Random effects analysis and independent component analysis (ICA) were used to compute activation maps. Results: Both analysis methods demonstrated alternative activation of cortical areas in children with perinatal stroke. Following perinatal stroke, typical left dominant productive language areas in the inferior frontal gyrus were displaced to anatomical identical areas in the right hemisphere (p = .001). In addition, stroke patients showed more bilateral activation in superior temporal and anterior cingulate gyri and increased activation in primary visual cortex when compared to healthy controls. There was no relation between lesion size and the degree of right hemisphere activation. ICA showed that the healthy controls had a negative correlation with the time course in the right inferior frontal gyrus in the same region that was activated in stroke subjects. Interpretation: This functional MRI study in children revealed novel patterns of cortical language reorganization following perinatal stroke. The addition of ICA is complementary to Random Effects Analysis, allowing for the exploration of potential subtle differences in pathways in functional MRI data obtained from both healthy and pathological groups.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalBrain and Language
Volume106
Issue number3
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Middle Cerebral Artery Infarction
stroke
reorganization
activation
brain
Language
Stroke
Magnetic Resonance Imaging
Brain
language
Prefrontal Cortex
Echo-Planar Imaging
Gyrus Cinguli
Executive Function
Visual Cortex
Activation
Reprint
Reorganization
interpretation
Independent Component Analysis

Keywords

  • Childhood
  • fMRI
  • Independent component analysis
  • Language
  • Random effects analysis
  • Stroke
  • Verb generation

ASJC Scopus subject areas

  • Language and Linguistics
  • Neuroscience(all)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Reprint of "Cortical reorganization of language functioning following perinatal left MCA stroke" [Brain and Language 105 (2008) 99-111]. / Tillema, Jan-Mendelt; Byars, Anna W.; Jacola, Lisa M.; Schapiro, Mark B.; Schmithorst, Vince J.; Szaflarski, Jerzy P.; Holland, Scott K.

In: Brain and Language, Vol. 106, No. 3, 09.2008, p. 184-194.

Research output: Contribution to journalArticle

Tillema, Jan-Mendelt ; Byars, Anna W. ; Jacola, Lisa M. ; Schapiro, Mark B. ; Schmithorst, Vince J. ; Szaflarski, Jerzy P. ; Holland, Scott K. / Reprint of "Cortical reorganization of language functioning following perinatal left MCA stroke" [Brain and Language 105 (2008) 99-111]. In: Brain and Language. 2008 ; Vol. 106, No. 3. pp. 184-194.
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