@article{97e2e7fb05814e80b522776b8697fc59,
title = "Reporting of sex as a variable in cardiovascular studies using cultured cells: A systematic review",
abstract = "Reporting the sex of biological material is critical for transparency and reproducibility in science. This study examined the reporting of the sex of cells used in cardiovascular studies. Articles from 16 cardiovascular journals that publish peer-reviewed studies in cardiovascular physiology and pharmacology in the year 2018 were systematically reviewed using terms “cultured” and “cells.” Data were collected on the sex of cells, the species from which the cells were isolated, and the type of cells, and summarized as a systematic review. Sex was reported in 88 (38.6%) of the 228 studies meeting inclusion criteria. Reporting rates varied with Circulation, Cardiovascular Research and American Journal of Physiology: Heart and Circulatory Physiology having the highest rates of sex reporting (>50%). A majority of the studies used cells from male (54.5%) or both male and female animals (32.9%). Humans (31.8%), rats (20.4%), and mice (43.8%) were the most common sources for cells. Cardiac myocytes were the most commonly used cell type (37.0%). Overall reporting of sex of experimental material remains below 50% and is inconsistent among journals. Sex chromosomes in cells have the potential to affect protein expression and molecular signaling pathways and should be consistently reported.",
keywords = "cardiology, cells, culture, endothelium, myocyte, sex, vascular smooth muscle",
author = "Saraschandra Vallabhajosyula and Ponamgi, {Shiva P.} and Sanskriti Shrivastava and Sundaragiri, {Pranathi R.} and Miller, {Virginia M.}",
note = "Funding Information: Dr Saraschandra Vallabhajosyula is supported by the Clinical and Translational Science Award (CTSA) Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. Dr Virginia M Miller is funded by the National Institutes of Health U54 AG 44170 and the Mayo Foundation This manuscript was written in the partial fulfillment of the requirements of BME 6855 Tutorial in Cardiovascular Physiology course for Dr Saraschandra Vallabhajosyula's Post-Doctoral Master's Degree Program with the Center for Clinical and Translational Science, Mayo Clinic Graduate School of Biomedical Sciences. Funding Information: Dr Saraschandra Vallabhajosyula is supported by the Clinical and Translational Science Award (CTSA) Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH. Dr Virginia M Miller is funded by the National Institutes of Health U54 AG 44170 and the Mayo Foundation Publisher Copyright: {\textcopyright} 2020 The Authors. The FASEB Journal published by Wiley Periodicals, Inc. on behalf of Federation of American Societies for Experimental Biology",
year = "2020",
month = jul,
day = "1",
doi = "10.1096/fj.202000122R",
language = "English (US)",
volume = "34",
pages = "8778--8786",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "7",
}