Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery

Mark F. Newman, Hilary P. Grocott, Joseph P. Mathew, William D. White, Kevin Landolfo, Joseph G. Reves, Daniel T. Laskowitz, Daniel B. Mark, James A. Blumenthal

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Background and Purpose - The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive function to the quality of life of patients and their families. The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery. Methods - After institutional review board approval and patient informed consent, 261 patients undergoing cardiac surgery with cardiopulmonary bypass were enrolled and followed for 5 years. Cognitive function was measured with a battery of tests at baseline, discharge, and 6 weeks and 5 years postoperatively. Quality of life was assessed with well-validated, standardized assessments at the 5-year end point. Results - Our results demonstrate significant correlations between cognitive function and quality of life in patients after cardiac surgery. Lower 5-year overall cognitive function scores were associated with lower general health and a less productive working status. Multivariable logistic and linear regression controlling for age, sex, education, and diabetes confirmed this strong association in the majority of areas of quality of life. Conclusions - Five years after cardiac surgery, there is a strong relationship between neurocognitive functioning and quality of life. This has important social and financial implications for preoperative evaluation and postoperative care of patients undergoing cardiac surgery.

Original languageEnglish (US)
Pages (from-to)2874-2879
Number of pages6
JournalStroke
Volume32
Issue number12
StatePublished - 2001
Externally publishedYes

Fingerprint

Thoracic Surgery
Quality of Life
Cognition
Preoperative Care
Sex Education
Postoperative Care
Research Ethics Committees
Informed Consent
Cardiopulmonary Bypass
Linear Models
Logistic Models
Cognitive Dysfunction
Health

Keywords

  • Cardiac surgical procedures
  • Cognitive disorders
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Newman, M. F., Grocott, H. P., Mathew, J. P., White, W. D., Landolfo, K., Reves, J. G., ... Blumenthal, J. A. (2001). Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke, 32(12), 2874-2879.

Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. / Newman, Mark F.; Grocott, Hilary P.; Mathew, Joseph P.; White, William D.; Landolfo, Kevin; Reves, Joseph G.; Laskowitz, Daniel T.; Mark, Daniel B.; Blumenthal, James A.

In: Stroke, Vol. 32, No. 12, 2001, p. 2874-2879.

Research output: Contribution to journalArticle

Newman, MF, Grocott, HP, Mathew, JP, White, WD, Landolfo, K, Reves, JG, Laskowitz, DT, Mark, DB & Blumenthal, JA 2001, 'Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery', Stroke, vol. 32, no. 12, pp. 2874-2879.
Newman MF, Grocott HP, Mathew JP, White WD, Landolfo K, Reves JG et al. Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke. 2001;32(12):2874-2879.
Newman, Mark F. ; Grocott, Hilary P. ; Mathew, Joseph P. ; White, William D. ; Landolfo, Kevin ; Reves, Joseph G. ; Laskowitz, Daniel T. ; Mark, Daniel B. ; Blumenthal, James A. / Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. In: Stroke. 2001 ; Vol. 32, No. 12. pp. 2874-2879.
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