Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States

Elizabeth A. Pomfret, Kenneth Washburn, Christoph Wald, Michael A. Nalesnik, David Douglas, Mark Russo, John Roberts, David J. Reich, Myron E. Schwartz, Luis Mieles, Fred T. Lee, Sander Florman, Francis Yao, Ann Harper, Erick Edwards, Richard Freeman, John Lake

Research output: Contribution to journalArticle

262 Citations (Scopus)

Abstract

A national conference was held to better characterize the long-term outcomes of liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) and to assess whether it is justified to continue the policy of assigning increased priority for candidates with early-stage HCC on the transplant waiting list in the United States. The objectives of the conference were to address specific HCC issues as they relate to liver allocation, develop a standardized pathology report form for the assessment of the explanted liver, develop more specific imaging criteria for HCC designed to qualify LT candidates for automatic Model for End-Stage Liver Disease (MELD) exception points without the need for biopsy, and develop a standardized pretransplant imaging report form for the assessment of patients with liver lesions. At the completion of the meeting, there was agreement that the allocation policy should result in similar risks of removal from the waiting list and similar transplant rates for HCC and non-HCC candidates. In addition, the allocation policy should select HCC candidates so that there are similar posttransplant outcomes for HCC and non-HCC recipients. There was a general consensus for the development of a calculated continuous HCC priority score for ranking HCC candidates on the list that would incorporate the calculated MELD score, alpha-fetoprotein, tumor size, and rate of tumor growth. Only candidates with at least stage T2 tumors would receive additional HCC priority points.

Original languageEnglish (US)
Pages (from-to)262-278
Number of pages17
JournalLiver Transplantation
Volume16
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Hepatocellular Carcinoma
Liver
End Stage Liver Disease
Waiting Lists
Liver Transplantation
Carcinoma
Transplants
Neoplasms
alpha-Fetoproteins
Consensus
Pathology
Biopsy
Growth

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Hepatology

Cite this

Pomfret, E. A., Washburn, K., Wald, C., Nalesnik, M. A., Douglas, D., Russo, M., ... Lake, J. (2010). Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States. Liver Transplantation, 16(3), 262-278. https://doi.org/10.1002/lt.21999

Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States. / Pomfret, Elizabeth A.; Washburn, Kenneth; Wald, Christoph; Nalesnik, Michael A.; Douglas, David; Russo, Mark; Roberts, John; Reich, David J.; Schwartz, Myron E.; Mieles, Luis; Lee, Fred T.; Florman, Sander; Yao, Francis; Harper, Ann; Edwards, Erick; Freeman, Richard; Lake, John.

In: Liver Transplantation, Vol. 16, No. 3, 03.2010, p. 262-278.

Research output: Contribution to journalArticle

Pomfret, EA, Washburn, K, Wald, C, Nalesnik, MA, Douglas, D, Russo, M, Roberts, J, Reich, DJ, Schwartz, ME, Mieles, L, Lee, FT, Florman, S, Yao, F, Harper, A, Edwards, E, Freeman, R & Lake, J 2010, 'Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States', Liver Transplantation, vol. 16, no. 3, pp. 262-278. https://doi.org/10.1002/lt.21999
Pomfret, Elizabeth A. ; Washburn, Kenneth ; Wald, Christoph ; Nalesnik, Michael A. ; Douglas, David ; Russo, Mark ; Roberts, John ; Reich, David J. ; Schwartz, Myron E. ; Mieles, Luis ; Lee, Fred T. ; Florman, Sander ; Yao, Francis ; Harper, Ann ; Edwards, Erick ; Freeman, Richard ; Lake, John. / Report of a national conference on liver allocation in patients with hepatocellular carcinoma in the United States. In: Liver Transplantation. 2010 ; Vol. 16, No. 3. pp. 262-278.
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