Repopulation of the liver with transplanted cells for novel cell and gene therapies

H. Malhi, S. Gupta

Research output: Contribution to journalReview article

Abstract

Recent advances in cell and molecular biology have provided ways to isolate, culture and manipulate hepatocytes, such as for expressing introduced genes. Moreover, genetically defined animal models have been utilized to localize transplanted hepatocytes in the liver and define their fate. Animal studies showed that transplanted hepatocytes become a part of the host liver, function normally and survive throughout the life span of rodents. Liver repopulation has captured much attention for its potential in treating liver disease, as well as for expressing therapeutic genes for genetic disorders. As further work concerning human hepatocytes comes to completion, significant new applications of hepatocyte transplantation will become established in the near future.

Original languageEnglish (US)
Pages (from-to)1221-1230
Number of pages10
JournalMedical Science Monitor
Volume5
Issue number6
StatePublished - Dec 1 1999

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Keywords

  • Gene expression
  • Hepatocyte
  • Liver
  • Transplantation
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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