Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

Yasuhiro Ikeda; Shin Ichi Itagaki; Shigeki Tsutsui; Yasuo Inoshima; Masashi Fukasawa; Keizo Tomonaga; Yukinobu Tohya; Ken Maeda; Masami Mochizuki; Takayuki Miyazawa; Takeshi Mikami

doi:10.1111/j.1348-0421.1997.tb01875.x

Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

Yasuhiro Ikeda, Shin Ichi Itagaki, Shigeki Tsutsui, Yasuo Inoshima, Masashi Fukasawa, Keizo Tomonaga, Yukinobu Tohya, Ken Maeda, Masami Mochizuki, Takayuki Miyazawa, Takeshi Mikami

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.

Original language	English (US)
Pages (from-to)	431-435
Number of pages	5
Journal	Microbiology and Immunology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1111/j.1348-0421.1997.tb01875.x
State	Published - 1997

Keywords

Apoptosis
Feline syncytial virus

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1348-0421.1997.tb01875.x

Cite this

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title = "Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells",

abstract = "Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.",

keywords = "Apoptosis, Feline syncytial virus",

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T1 - Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

AU - Ikeda, Yasuhiro

AU - Itagaki, Shin Ichi

AU - Tsutsui, Shigeki

AU - Inoshima, Yasuo

AU - Fukasawa, Masashi

AU - Tomonaga, Keizo

AU - Tohya, Yukinobu

AU - Maeda, Ken

AU - Mochizuki, Masami

AU - Miyazawa, Takayuki

AU - Mikami, Takeshi

PY - 1997

Y1 - 1997

N2 - Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.

AB - Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.

KW - Apoptosis

KW - Feline syncytial virus

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DO - 10.1111/j.1348-0421.1997.tb01875.x

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Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

Abstract

Keywords

ASJC Scopus subject areas

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