Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells

Yasuhiro H Ikeda, Shin Ichi Itagaki, Shigeki Tsutsui, Yasuo Inoshima, Masashi Fukasawa, Keizo Tomonaga, Yukinobu Tohya, Ken Maeda, Masami Mochizuki, Takayuki Miyazawa, Takeshi Mikami

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalMicrobiology and Immunology
Volume41
Issue number5
StatePublished - 1997
Externally publishedYes

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Felidae
Apoptosis
Viruses
Biodiversity
DNA Fragmentation
Giant Cells
Chromatin
Blood Cells
Cats
Lymphocytes
T-Lymphocytes
Antigens

Keywords

  • Apoptosis
  • Feline syncytial virus

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Ikeda, Y. H., Itagaki, S. I., Tsutsui, S., Inoshima, Y., Fukasawa, M., Tomonaga, K., ... Mikami, T. (1997). Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells. Microbiology and Immunology, 41(5), 431-435.

Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells. / Ikeda, Yasuhiro H; Itagaki, Shin Ichi; Tsutsui, Shigeki; Inoshima, Yasuo; Fukasawa, Masashi; Tomonaga, Keizo; Tohya, Yukinobu; Maeda, Ken; Mochizuki, Masami; Miyazawa, Takayuki; Mikami, Takeshi.

In: Microbiology and Immunology, Vol. 41, No. 5, 1997, p. 431-435.

Research output: Contribution to journalArticle

Ikeda, YH, Itagaki, SI, Tsutsui, S, Inoshima, Y, Fukasawa, M, Tomonaga, K, Tohya, Y, Maeda, K, Mochizuki, M, Miyazawa, T & Mikami, T 1997, 'Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells', Microbiology and Immunology, vol. 41, no. 5, pp. 431-435.
Ikeda YH, Itagaki SI, Tsutsui S, Inoshima Y, Fukasawa M, Tomonaga K et al. Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells. Microbiology and Immunology. 1997;41(5):431-435.
Ikeda, Yasuhiro H ; Itagaki, Shin Ichi ; Tsutsui, Shigeki ; Inoshima, Yasuo ; Fukasawa, Masashi ; Tomonaga, Keizo ; Tohya, Yukinobu ; Maeda, Ken ; Mochizuki, Masami ; Miyazawa, Takayuki ; Mikami, Takeshi. / Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells. In: Microbiology and Immunology. 1997 ; Vol. 41, No. 5. pp. 431-435.
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