Replication of CLU, CR1, and PICALM associations with Alzheimer disease

Minerva M Carrasquillo, Olivia Belbin, Talisha A. Hunter, Li Ma, Gina D. Bisceglio, Fanggeng Zou, Juliana Crook, V. Shane Pankratz, Dennis W Dickson, Neill R Graff Radford, Ronald Carl Petersen, Kevin Morgan, Steven G Younkin

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Objective: To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease. Design: Follow-up case-control association study. Setting: The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota. Participants: Community-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were seen at the Mayo clinics, and autopsy-confirmed cases and controls whose pathology was evaluated at the Mayo Clinic in Jacksonville. Additional samples were obtained from the National Cell Repository for Alzheimer Disease (NCRAD).Atotal of 1829 LOAD cases and 2576 controls were analyzed. Interventions: The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. Main Outcome Measure: Clinical or pathology-confirmed diagnosis of LOAD. Results: Odds ratios forCLU, CR1, and PICALM were 0.82, 1.15, and 0.80, respectively, comparable in direction and magnitude with those originally reported. P values were 8.6 × 10-5, .014, and 1.3 × 10-5, respectively; they remain significant even after Bonferroni correction for the 3 single-nucleotide polymorphisms tested. Conclusion: These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD.

Original languageEnglish (US)
Pages (from-to)961-964
Number of pages4
JournalArchives of Neurology
Volume67
Issue number8
DOIs
StatePublished - Aug 2010

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Alzheimer Disease
Single Nucleotide Polymorphism
Clinical Pathology
Alzheimer's Disease
Replication
Dementia
Case-Control Studies
Autopsy
Odds Ratio
Outcome Assessment (Health Care)
Onset
Pathology
Genes
Clinic
Polymorphism

ASJC Scopus subject areas

  • Clinical Neurology

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Replication of CLU, CR1, and PICALM associations with Alzheimer disease. / Carrasquillo, Minerva M; Belbin, Olivia; Hunter, Talisha A.; Ma, Li; Bisceglio, Gina D.; Zou, Fanggeng; Crook, Juliana; Pankratz, V. Shane; Dickson, Dennis W; Graff Radford, Neill R; Petersen, Ronald Carl; Morgan, Kevin; Younkin, Steven G.

In: Archives of Neurology, Vol. 67, No. 8, 08.2010, p. 961-964.

Research output: Contribution to journalArticle

Carrasquillo, Minerva M ; Belbin, Olivia ; Hunter, Talisha A. ; Ma, Li ; Bisceglio, Gina D. ; Zou, Fanggeng ; Crook, Juliana ; Pankratz, V. Shane ; Dickson, Dennis W ; Graff Radford, Neill R ; Petersen, Ronald Carl ; Morgan, Kevin ; Younkin, Steven G. / Replication of CLU, CR1, and PICALM associations with Alzheimer disease. In: Archives of Neurology. 2010 ; Vol. 67, No. 8. pp. 961-964.
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