Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects

H. C. Haverkamp, J. A. Dempsey, Jordan D Miller, L. M. Romer, D. F. Pegelow, A. T. Lovering, M. W. Eldridge

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Twenty-one subjects with asthma underwent treadmill exercise to exhaustion at a workload that elicited ∼90% of each subject's maximal O 2 uptake (EX1). After EX1, 12 subjects experienced significant exercise-induced bronchospasm [(EIB +), %decrease in forced expiratory volume in 1.0 s = -24.0 ± 11.5%; pulmonary resistance at rest vs. postexercise = 3.2 ± 1.5 vs. 8.1 ± 4.5 cmH 2O·1 -1·s -1] and nine did not (EIB -). The alveolar-to-arterial PO 2 difference (A-aDO 2) was widened from rest (9.1 ± 6.7 Torr) to 23.1 ± 10.4 and 18.1 ± 9.1 Torr at 35 min after EX1 in subjects with and without EIB, respectively (P < 0.05). Arterial PO 2 (PaO 2) was reduced in both groups during recovery (EIB +, -16.0 ± -13.0 Torr vs. baseline; EIB -, -11.0 ± 9.4 Torr vs. baseline, P ≤ 0.05). Forty minutes after EX1, a second exercise bout was completed at maximal O 2 uptake. During the second exercise bout, pulmonary resistance decreased to baseline levels in the EIB + group and the A-aDO 2 and PaO 2 returned to match the values seen during EX1 in both groups. Sputum histamine (34.6 ± 25.9 vs. 61.2 ± 42.0 ng/ml, pre- vs. postexercise) and urinary 9α,11β-prostaglandin F 2 (74.5 ± 38.6 vs. 164.6 ± 84.2 ng/mmol creatinine, pre- vs. postexercise) were increased after exercise only in the EIB + group (P < 0.05), and postexercise sputum histamine was significantly correlated with the exercise PaO 2 and A-aDO 2 in the EIB + subjects. Thus exercise causes gas-exchange impairment during the postexercise period in asthmatic subjects independent of decreases in forced expiratory flow rates after the exercise; however, a subsequent exercise bout normalizes this impairment secondary in part to a fast acting, robust exercise-induced bronchodilatory response.

Original languageEnglish (US)
Pages (from-to)1843-1852
Number of pages10
JournalJournal of Applied Physiology
Volume99
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Sputum
Histamine
Forced Expiratory Flow Rates
Gases
Exercise-Induced Asthma
Lung
Forced Expiratory Volume
Prostaglandins F
Workload
Creatinine
Asthma
PO-2

Keywords

  • Airway inflammation
  • Alveolar-to-arterial oxygen difference
  • Bronchodilation
  • Exercise-induced bronchospasm
  • Pulmonary resistance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Haverkamp, H. C., Dempsey, J. A., Miller, J. D., Romer, L. M., Pegelow, D. F., Lovering, A. T., & Eldridge, M. W. (2005). Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects. Journal of Applied Physiology, 99(5), 1843-1852. https://doi.org/10.1152/japplphysiol.01399.2004

Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects. / Haverkamp, H. C.; Dempsey, J. A.; Miller, Jordan D; Romer, L. M.; Pegelow, D. F.; Lovering, A. T.; Eldridge, M. W.

In: Journal of Applied Physiology, Vol. 99, No. 5, 11.2005, p. 1843-1852.

Research output: Contribution to journalArticle

Haverkamp, HC, Dempsey, JA, Miller, JD, Romer, LM, Pegelow, DF, Lovering, AT & Eldridge, MW 2005, 'Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects', Journal of Applied Physiology, vol. 99, no. 5, pp. 1843-1852. https://doi.org/10.1152/japplphysiol.01399.2004
Haverkamp, H. C. ; Dempsey, J. A. ; Miller, Jordan D ; Romer, L. M. ; Pegelow, D. F. ; Lovering, A. T. ; Eldridge, M. W. / Repeat exercise normalizes the gas-exchange impairment induced by a previous exercise bout in asthmatic subjects. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 5. pp. 1843-1852.
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