Renovascular hypertension in 2007

Where are we now?

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Hypertension inpatients with renovascular disease poses a major clinical challenge. Renal arterial disease accelerates hypertension by activation of multiple pressor systems. Although younger individuals with fibromuscular lesions often respond well to angioplasty with minor associated risks, care must be taken in cases of complex vascular anomalies, such as renal artery aneurysms. More than 85% of patients referred for revascularization have atherosclerotic renal artery stenosis; most are older patients with preexisting hypertension, diabetes, and vascular disease. The benefits of stent revascularization in this group are controversial. Antihypertensive therapy works best with drugs that block the renin-angiotensin system; however, most patients require multiple agents. Detailed analysis of the literature and small prospective trials failed to identify major benefits with renal artery angioplasty as compared with intensive drug therapy. The CORAL study and others seek to randomly assign subjects with high-grade renovascular lesions to optimal medical management with and without stenting.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalCurrent Cardiology Reports
Volume9
Issue number6
DOIs
StatePublished - Nov 2007

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Renovascular Hypertension
Renal Artery
Hypertension
Angioplasty
Renal Artery Obstruction
Renin-Angiotensin System
Vascular Diseases
Antihypertensive Agents
Stents
Aneurysm
Blood Vessels
Inpatients
Kidney
Drug Therapy
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Renovascular hypertension in 2007 : Where are we now? / Textor, Stephen C.

In: Current Cardiology Reports, Vol. 9, No. 6, 11.2007, p. 453-461.

Research output: Contribution to journalArticle

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