Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases

Sandra M. Herrmann; Mariam P. Alexander; Michael F. Romero; Ladan Zand

doi:10.1016/j.xkme.2020.05.015

Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases

Sandra M. Herrmann, Mariam P. Alexander, Michael F. Romero, Ladan Zand

Research output: Contribution to journal › Article › peer-review

Abstract

The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.

Original language	English (US)
Pages (from-to)	657-662
Number of pages	6
Journal	Kidney Medicine
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/j.xkme.2020.05.015
State	Published - Sep 1 2020

Keywords

Immune checkpoint inhibitors
PD-1 inhibitor
acute interstitial nephritis
case report
immune-related adverse event
renal tubular acidosis

ASJC Scopus subject areas

Internal Medicine
Nephrology

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10.1016/j.xkme.2020.05.015

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title = "Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases",

abstract = "The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.",

keywords = "Immune checkpoint inhibitors, PD-1 inhibitor, acute interstitial nephritis, case report, immune-related adverse event, renal tubular acidosis",

author = "Herrmann, {Sandra M.} and Alexander, {Mariam P.} and Romero, {Michael F.} and Ladan Zand",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

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language = "English (US)",

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T2 - An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases

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AU - Alexander, Mariam P.

AU - Romero, Michael F.

AU - Zand, Ladan

PY - 2020/9/1

Y1 - 2020/9/1

N2 - The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.

AB - The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.

KW - Immune checkpoint inhibitors

KW - PD-1 inhibitor

KW - acute interstitial nephritis

KW - case report

KW - immune-related adverse event

KW - renal tubular acidosis

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Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor—A Report of 3 Cases

Abstract

Keywords

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