Renal transplants

Can acute rejection and acute tubular necrosis be differentiated with MR imaging?

J. T.S. Liou, J. K.T. Lee, Jay Heiken, W. G. Totty, P. L. Molina, W. M. Flye

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Magnetic resonance (MR) imaging was used in 40 renal transplant recipients to determine whether this modality can enable distinction of acute tubular necrosis (ATN) and acute rejection by means of corticomedullary differentiation (CMD). Each patient underwent initial MR imaging after allograft renal transplantation. Twenty-nine of these 40 patients (72%) also underwent subsequent follow-up MR imaging. Seventeen studies were obtained during episodes of ATN; 12 of these studies (71%) showed poor CMD. Eleven studies were obtained during episodes of acute rejection; eight of these studies (73%) showed poor CMD. In addition, six of seven studies (86%) showing various combinations of renal disease (ATN, acute rejection, chronic rejection, and cyclosporine toxicity) also showed poor CMD. Loss of CMD is reversible after improvement of ATN and acute rejection. Because loss of CMD is a nonspecific though sensitive sign reflecting renal transplant dysfunction, MR imaging is of limited value in the differentiation of ATN from acute rejection.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalRadiology
Volume179
Issue number1
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Necrosis
Magnetic Resonance Imaging
Transplants
Kidney
Acute Disease
Kidney Transplantation
Cyclosporine
Allografts

Keywords

  • Kidney, MR studies, 81.1214
  • Kidney, necrosis, 81.4553
  • Kidney, transplantation, 81.4552

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Renal transplants : Can acute rejection and acute tubular necrosis be differentiated with MR imaging? / Liou, J. T.S.; Lee, J. K.T.; Heiken, Jay; Totty, W. G.; Molina, P. L.; Flye, W. M.

In: Radiology, Vol. 179, No. 1, 01.01.1991, p. 61-65.

Research output: Contribution to journalArticle

Liou, J. T.S. ; Lee, J. K.T. ; Heiken, Jay ; Totty, W. G. ; Molina, P. L. ; Flye, W. M. / Renal transplants : Can acute rejection and acute tubular necrosis be differentiated with MR imaging?. In: Radiology. 1991 ; Vol. 179, No. 1. pp. 61-65.
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