Renal transplantation in Alport's syndrome. Anti-glomerular basement membrane. Glomerulonephritis in the allograft

D. S. Milliner, A. M. Pierides, K. E. Holley

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Abstract

Eleven patients with Alport's syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients received a second allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of two of the three patients; circulating antiglomerular basement membrane antibodies were present in one patient. These two patients had successful retransplantation and they remain well 1 1/2 and 4 1/2 years later. Renal transplantation in patients with Alport's syndrome is a worthwhile and very satisfactory procedure.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalMayo Clinic Proceedings
Volume57
Issue number1
StatePublished - 1982

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Hereditary Nephritis
Glomerular Basement Membrane
Glomerulonephritis
Kidney Transplantation
Allografts
Creatinine
Immunoglobulin G
Staining and Labeling
Transplants
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Renal transplantation in Alport's syndrome. Anti-glomerular basement membrane. Glomerulonephritis in the allograft. / Milliner, D. S.; Pierides, A. M.; Holley, K. E.

In: Mayo Clinic Proceedings, Vol. 57, No. 1, 1982, p. 35-43.

Research output: Contribution to journalArticle

Milliner, D. S. ; Pierides, A. M. ; Holley, K. E. / Renal transplantation in Alport's syndrome. Anti-glomerular basement membrane. Glomerulonephritis in the allograft. In: Mayo Clinic Proceedings. 1982 ; Vol. 57, No. 1. pp. 35-43.
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