Renal transplant pathology: An update

Robert B. Colvin, Lynn D. Cornell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Renal transplant pathology occupies an ever-changing spectrum, due to new techniques and drugs. Acute and chronic antibody-mediated rejection is diagnosed by a combination of light, immunofluorescence (C4d) and electron microscopic features, and these newly recognized diseases are now in the Banff schema. C4d deposition, with normal graft histology, is a sign of accommodation, most common in ABO-incompatible grafts. Chronic allograft nephropathy has been removed from the Banff system in an attempt to promote more specific diagnosis and treatment of the causes of late graft injury. A new aspect of polyomavirus is the formation of immune complexes along tubular basement membranes. Rapamycin causes lesions resembling myeloma cast nephropathy and exacerbates proteinuria, probably due to tubular and/or glomerular toxicity. Protocol biopsies, now part of routine care in many centers, detect the early stages of pathological processes, such as subclinical rejection, polyomavirus infection or transplant glomerulopathy, when they are potentially treatable.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalCurrent Diagnostic Pathology
Volume13
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Pathology
Transplants
Kidney
Polyomavirus Infections
Polyomavirus
Pathologic Processes
Sirolimus
Antigen-Antibody Complex
Proteinuria
Basement Membrane
Fluorescent Antibody Technique
Allografts
Histology
Electrons
Biopsy
Light
Antibodies
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

Keywords

  • Drug toxicity
  • Rejection
  • Renal transplant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Renal transplant pathology : An update. / Colvin, Robert B.; Cornell, Lynn D.

In: Current Diagnostic Pathology, Vol. 13, No. 1, 02.2007, p. 15-24.

Research output: Contribution to journalArticle

Colvin, Robert B. ; Cornell, Lynn D. / Renal transplant pathology : An update. In: Current Diagnostic Pathology. 2007 ; Vol. 13, No. 1. pp. 15-24.
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