Renal transplant function after ten years of cyclosporine

P. S. Almond, K. J. Gillingham, R. Sibley, A. Moss, M. Melin, J. Leventhal, C. Manivel, P. Kyriakides, W. D. Payne, D. L. Dunn, D. E. Sutherl, P. F. Gores, J. S. Najarian, Arthur J. Matas

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Although the nephrotoxic side effects of cyclosporine are well known, the impact of long-term CsA on renal transplant function is uncertain. We studied 5-10-year renal function in 347 CsA-treated patients, and in 64 randomly selected non-CsA-treated patients who had a minimum of 55 months of graft function. Non-CsA patients had a lower creatinine (Cr) level at one year than CsA patients (f=.001), with no change in renal function over time (P=.6). In CsA-treated patients there was also no suggestion of progressive renal damage, as evidenced by no change in Cr or 1/Cr. Simple linear regression models of 1/Cr vs. time for the first 10 years posttrans-plant were fit to the data for each patient. Analysis of the Y-intercept estimates from these regressions showed that age (P=.001), sex (P=.001), cyclosporine toxicity (P=.024), and initial cyclosporine dosage (P=.016) significantly affected the one-year serum Cr. Variables not affecting one-year Cr included donor source, early rejection episodes, late rejection ep sodes, ATN, diabetes, transplant number, HLA ABDR mismatch (for cadaver transplants), maximum PR A, and PRA at transplant. Analysis of the slope estimates from the regressions revealed that only age (P=.001) and late rejection episodes (P=.001) significantly affected the rate of change in 1/Cr over time. We conclude that, in long-term renal transplant patients, there is no evidence of progressive deterioration in renal function due to CsA nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)316-323
Number of pages8
JournalTransplantation
Volume53
Issue number2
StatePublished - 1992
Externally publishedYes

Fingerprint

Cyclosporine
Creatinine
Transplants
Kidney
Linear Models
Cadaver
Tissue Donors
Serum

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Almond, P. S., Gillingham, K. J., Sibley, R., Moss, A., Melin, M., Leventhal, J., ... Matas, A. J. (1992). Renal transplant function after ten years of cyclosporine. Transplantation, 53(2), 316-323.

Renal transplant function after ten years of cyclosporine. / Almond, P. S.; Gillingham, K. J.; Sibley, R.; Moss, A.; Melin, M.; Leventhal, J.; Manivel, C.; Kyriakides, P.; Payne, W. D.; Dunn, D. L.; Sutherl, D. E.; Gores, P. F.; Najarian, J. S.; Matas, Arthur J.

In: Transplantation, Vol. 53, No. 2, 1992, p. 316-323.

Research output: Contribution to journalArticle

Almond, PS, Gillingham, KJ, Sibley, R, Moss, A, Melin, M, Leventhal, J, Manivel, C, Kyriakides, P, Payne, WD, Dunn, DL, Sutherl, DE, Gores, PF, Najarian, JS & Matas, AJ 1992, 'Renal transplant function after ten years of cyclosporine', Transplantation, vol. 53, no. 2, pp. 316-323.
Almond PS, Gillingham KJ, Sibley R, Moss A, Melin M, Leventhal J et al. Renal transplant function after ten years of cyclosporine. Transplantation. 1992;53(2):316-323.
Almond, P. S. ; Gillingham, K. J. ; Sibley, R. ; Moss, A. ; Melin, M. ; Leventhal, J. ; Manivel, C. ; Kyriakides, P. ; Payne, W. D. ; Dunn, D. L. ; Sutherl, D. E. ; Gores, P. F. ; Najarian, J. S. ; Matas, Arthur J. / Renal transplant function after ten years of cyclosporine. In: Transplantation. 1992 ; Vol. 53, No. 2. pp. 316-323.
@article{0c07a4f8f2a440c8982fc31e3e5533ce,
title = "Renal transplant function after ten years of cyclosporine",
abstract = "Although the nephrotoxic side effects of cyclosporine are well known, the impact of long-term CsA on renal transplant function is uncertain. We studied 5-10-year renal function in 347 CsA-treated patients, and in 64 randomly selected non-CsA-treated patients who had a minimum of 55 months of graft function. Non-CsA patients had a lower creatinine (Cr) level at one year than CsA patients (f=.001), with no change in renal function over time (P=.6). In CsA-treated patients there was also no suggestion of progressive renal damage, as evidenced by no change in Cr or 1/Cr. Simple linear regression models of 1/Cr vs. time for the first 10 years posttrans-plant were fit to the data for each patient. Analysis of the Y-intercept estimates from these regressions showed that age (P=.001), sex (P=.001), cyclosporine toxicity (P=.024), and initial cyclosporine dosage (P=.016) significantly affected the one-year serum Cr. Variables not affecting one-year Cr included donor source, early rejection episodes, late rejection ep sodes, ATN, diabetes, transplant number, HLA ABDR mismatch (for cadaver transplants), maximum PR A, and PRA at transplant. Analysis of the slope estimates from the regressions revealed that only age (P=.001) and late rejection episodes (P=.001) significantly affected the rate of change in 1/Cr over time. We conclude that, in long-term renal transplant patients, there is no evidence of progressive deterioration in renal function due to CsA nephrotoxicity.",
author = "Almond, {P. S.} and Gillingham, {K. J.} and R. Sibley and A. Moss and M. Melin and J. Leventhal and C. Manivel and P. Kyriakides and Payne, {W. D.} and Dunn, {D. L.} and Sutherl, {D. E.} and Gores, {P. F.} and Najarian, {J. S.} and Matas, {Arthur J.}",
year = "1992",
language = "English (US)",
volume = "53",
pages = "316--323",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Renal transplant function after ten years of cyclosporine

AU - Almond, P. S.

AU - Gillingham, K. J.

AU - Sibley, R.

AU - Moss, A.

AU - Melin, M.

AU - Leventhal, J.

AU - Manivel, C.

AU - Kyriakides, P.

AU - Payne, W. D.

AU - Dunn, D. L.

AU - Sutherl, D. E.

AU - Gores, P. F.

AU - Najarian, J. S.

AU - Matas, Arthur J.

PY - 1992

Y1 - 1992

N2 - Although the nephrotoxic side effects of cyclosporine are well known, the impact of long-term CsA on renal transplant function is uncertain. We studied 5-10-year renal function in 347 CsA-treated patients, and in 64 randomly selected non-CsA-treated patients who had a minimum of 55 months of graft function. Non-CsA patients had a lower creatinine (Cr) level at one year than CsA patients (f=.001), with no change in renal function over time (P=.6). In CsA-treated patients there was also no suggestion of progressive renal damage, as evidenced by no change in Cr or 1/Cr. Simple linear regression models of 1/Cr vs. time for the first 10 years posttrans-plant were fit to the data for each patient. Analysis of the Y-intercept estimates from these regressions showed that age (P=.001), sex (P=.001), cyclosporine toxicity (P=.024), and initial cyclosporine dosage (P=.016) significantly affected the one-year serum Cr. Variables not affecting one-year Cr included donor source, early rejection episodes, late rejection ep sodes, ATN, diabetes, transplant number, HLA ABDR mismatch (for cadaver transplants), maximum PR A, and PRA at transplant. Analysis of the slope estimates from the regressions revealed that only age (P=.001) and late rejection episodes (P=.001) significantly affected the rate of change in 1/Cr over time. We conclude that, in long-term renal transplant patients, there is no evidence of progressive deterioration in renal function due to CsA nephrotoxicity.

AB - Although the nephrotoxic side effects of cyclosporine are well known, the impact of long-term CsA on renal transplant function is uncertain. We studied 5-10-year renal function in 347 CsA-treated patients, and in 64 randomly selected non-CsA-treated patients who had a minimum of 55 months of graft function. Non-CsA patients had a lower creatinine (Cr) level at one year than CsA patients (f=.001), with no change in renal function over time (P=.6). In CsA-treated patients there was also no suggestion of progressive renal damage, as evidenced by no change in Cr or 1/Cr. Simple linear regression models of 1/Cr vs. time for the first 10 years posttrans-plant were fit to the data for each patient. Analysis of the Y-intercept estimates from these regressions showed that age (P=.001), sex (P=.001), cyclosporine toxicity (P=.024), and initial cyclosporine dosage (P=.016) significantly affected the one-year serum Cr. Variables not affecting one-year Cr included donor source, early rejection episodes, late rejection ep sodes, ATN, diabetes, transplant number, HLA ABDR mismatch (for cadaver transplants), maximum PR A, and PRA at transplant. Analysis of the slope estimates from the regressions revealed that only age (P=.001) and late rejection episodes (P=.001) significantly affected the rate of change in 1/Cr over time. We conclude that, in long-term renal transplant patients, there is no evidence of progressive deterioration in renal function due to CsA nephrotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0026507256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026507256&partnerID=8YFLogxK

M3 - Article

C2 - 1738925

AN - SCOPUS:0026507256

VL - 53

SP - 316

EP - 323

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -