Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort

Arlene B. Chapman, Lisa M. Guay-Woodford, Jared J. Grantham, Vicente Torres, Kyongtae T. Bae, Deborah A. Baumgarten, Philip J. Kenney, Bernard Francis King, James Glockner, Louis H. Wetzel, Marijn E. Brummer, W. Charles O'Neill, Michelle L. Robbin, William M. Bennett, Saulo Klahr, Gladys H. Hirschman, Paul L. Kimmel, Paul A. Thompson, J. Philip Miller

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Background. Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by gradual renal enlargement and cyst growth prior to loss of renal function. Standard radiographic imaging has not provided the resolution and accuracy necessary to detect small changes in renal volume or to reliably measure renal cyst volumes. The Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP) is longitudinally observing ADPKD individuals using high-resolution magnetic resonance (MR) imaging to determine if change in renal and cyst volumes can be detected over a short period of time, and if they correlate with decline in renal function early in disease. Methods. Standardization studies were conducted in phantoms and four subjects at each participating clinical center. After, in the full-scale protocol, healthy ADPKD individuals 15 to 45 years old with creatinine clearance >70 mL/min underwent standardized MR renal imaging, renal iothalamate clearance, comprehensive clinical evaluation, and determination of 24-hour urinary albumin and electrolyte excretion. Stereology was used from T1-weighted images to quantify renal volume, and region-growing thresholding was used from T2-weighted images to determine cyst volume. Renal structures were evaluated in relation to demographic, clinical, and biochemical variables using means/medians, standard deviations, and Pearson correlations. Results. Reliability coefficients for MR renal and cyst volume measurements in phantoms were 99.9% and 89.2%, respectively. In the full-scale protocol, 241 ADPKD individuals (145 women and 96 men) were enrolled. Total renal, cyst, and % cyst volume were significantly greater in each decade group. Hypertensive individuals demonstrated greater renal, cyst, and % cyst volume than normotensive subjects. Age-adjusted renal (r = -0.31, P < 0.0001), cyst (r = -0.36, P < 0.0001), and % cyst volume (r = -0.35, P < 0.0001) were inversely related to glomerular filtration rate (GFR). Age-adjusted renal volume (r = 0.42, P < 0.0001), cystic (r = 0.39, P < 0.0001, and % cyst volume (r = 0.41, P < 0.0001) were related with urinary albumin excretion. Conclusion. MR measures of renal and cyst volume are reliable and accurate in patients with ADPKD. ADPKD is characterized by significant cystic involvement that increases with age. Structure (renal and cyst volume) and function (GFR) are inversely related and directly related with the presence of hypertension and urinary albumin excretion in individuals with normal renal function.

Original languageEnglish (US)
Pages (from-to)1035-1045
Number of pages11
JournalKidney International
Volume64
Issue number3
DOIs
StatePublished - Sep 1 2003

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Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
Cysts
Kidney
Albumins
Glomerular Filtration Rate
Magnetic Resonance Spectroscopy
Iothalamic Acid
Magnetic Resonance Imaging

Keywords

  • Autosomal-dominant polycystic kidney disease
  • Cyst volume
  • Magnetic resonance imaging
  • Renal function
  • Renal volume

ASJC Scopus subject areas

  • Nephrology

Cite this

Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD) : The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. / Chapman, Arlene B.; Guay-Woodford, Lisa M.; Grantham, Jared J.; Torres, Vicente; Bae, Kyongtae T.; Baumgarten, Deborah A.; Kenney, Philip J.; King, Bernard Francis; Glockner, James; Wetzel, Louis H.; Brummer, Marijn E.; O'Neill, W. Charles; Robbin, Michelle L.; Bennett, William M.; Klahr, Saulo; Hirschman, Gladys H.; Kimmel, Paul L.; Thompson, Paul A.; Miller, J. Philip.

In: Kidney International, Vol. 64, No. 3, 01.09.2003, p. 1035-1045.

Research output: Contribution to journalArticle

Chapman, AB, Guay-Woodford, LM, Grantham, JJ, Torres, V, Bae, KT, Baumgarten, DA, Kenney, PJ, King, BF, Glockner, J, Wetzel, LH, Brummer, ME, O'Neill, WC, Robbin, ML, Bennett, WM, Klahr, S, Hirschman, GH, Kimmel, PL, Thompson, PA & Miller, JP 2003, 'Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort', Kidney International, vol. 64, no. 3, pp. 1035-1045. https://doi.org/10.1046/j.1523-1755.2003.00185.x
Chapman, Arlene B. ; Guay-Woodford, Lisa M. ; Grantham, Jared J. ; Torres, Vicente ; Bae, Kyongtae T. ; Baumgarten, Deborah A. ; Kenney, Philip J. ; King, Bernard Francis ; Glockner, James ; Wetzel, Louis H. ; Brummer, Marijn E. ; O'Neill, W. Charles ; Robbin, Michelle L. ; Bennett, William M. ; Klahr, Saulo ; Hirschman, Gladys H. ; Kimmel, Paul L. ; Thompson, Paul A. ; Miller, J. Philip. / Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD) : The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. In: Kidney International. 2003 ; Vol. 64, No. 3. pp. 1035-1045.
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abstract = "Background. Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by gradual renal enlargement and cyst growth prior to loss of renal function. Standard radiographic imaging has not provided the resolution and accuracy necessary to detect small changes in renal volume or to reliably measure renal cyst volumes. The Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP) is longitudinally observing ADPKD individuals using high-resolution magnetic resonance (MR) imaging to determine if change in renal and cyst volumes can be detected over a short period of time, and if they correlate with decline in renal function early in disease. Methods. Standardization studies were conducted in phantoms and four subjects at each participating clinical center. After, in the full-scale protocol, healthy ADPKD individuals 15 to 45 years old with creatinine clearance >70 mL/min underwent standardized MR renal imaging, renal iothalamate clearance, comprehensive clinical evaluation, and determination of 24-hour urinary albumin and electrolyte excretion. Stereology was used from T1-weighted images to quantify renal volume, and region-growing thresholding was used from T2-weighted images to determine cyst volume. Renal structures were evaluated in relation to demographic, clinical, and biochemical variables using means/medians, standard deviations, and Pearson correlations. Results. Reliability coefficients for MR renal and cyst volume measurements in phantoms were 99.9{\%} and 89.2{\%}, respectively. In the full-scale protocol, 241 ADPKD individuals (145 women and 96 men) were enrolled. Total renal, cyst, and {\%} cyst volume were significantly greater in each decade group. Hypertensive individuals demonstrated greater renal, cyst, and {\%} cyst volume than normotensive subjects. Age-adjusted renal (r = -0.31, P < 0.0001), cyst (r = -0.36, P < 0.0001), and {\%} cyst volume (r = -0.35, P < 0.0001) were inversely related to glomerular filtration rate (GFR). Age-adjusted renal volume (r = 0.42, P < 0.0001), cystic (r = 0.39, P < 0.0001, and {\%} cyst volume (r = 0.41, P < 0.0001) were related with urinary albumin excretion. Conclusion. MR measures of renal and cyst volume are reliable and accurate in patients with ADPKD. ADPKD is characterized by significant cystic involvement that increases with age. Structure (renal and cyst volume) and function (GFR) are inversely related and directly related with the presence of hypertension and urinary albumin excretion in individuals with normal renal function.",
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TY - JOUR

T1 - Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD)

T2 - The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort

AU - Chapman, Arlene B.

AU - Guay-Woodford, Lisa M.

AU - Grantham, Jared J.

AU - Torres, Vicente

AU - Bae, Kyongtae T.

AU - Baumgarten, Deborah A.

AU - Kenney, Philip J.

AU - King, Bernard Francis

AU - Glockner, James

AU - Wetzel, Louis H.

AU - Brummer, Marijn E.

AU - O'Neill, W. Charles

AU - Robbin, Michelle L.

AU - Bennett, William M.

AU - Klahr, Saulo

AU - Hirschman, Gladys H.

AU - Kimmel, Paul L.

AU - Thompson, Paul A.

AU - Miller, J. Philip

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background. Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by gradual renal enlargement and cyst growth prior to loss of renal function. Standard radiographic imaging has not provided the resolution and accuracy necessary to detect small changes in renal volume or to reliably measure renal cyst volumes. The Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP) is longitudinally observing ADPKD individuals using high-resolution magnetic resonance (MR) imaging to determine if change in renal and cyst volumes can be detected over a short period of time, and if they correlate with decline in renal function early in disease. Methods. Standardization studies were conducted in phantoms and four subjects at each participating clinical center. After, in the full-scale protocol, healthy ADPKD individuals 15 to 45 years old with creatinine clearance >70 mL/min underwent standardized MR renal imaging, renal iothalamate clearance, comprehensive clinical evaluation, and determination of 24-hour urinary albumin and electrolyte excretion. Stereology was used from T1-weighted images to quantify renal volume, and region-growing thresholding was used from T2-weighted images to determine cyst volume. Renal structures were evaluated in relation to demographic, clinical, and biochemical variables using means/medians, standard deviations, and Pearson correlations. Results. Reliability coefficients for MR renal and cyst volume measurements in phantoms were 99.9% and 89.2%, respectively. In the full-scale protocol, 241 ADPKD individuals (145 women and 96 men) were enrolled. Total renal, cyst, and % cyst volume were significantly greater in each decade group. Hypertensive individuals demonstrated greater renal, cyst, and % cyst volume than normotensive subjects. Age-adjusted renal (r = -0.31, P < 0.0001), cyst (r = -0.36, P < 0.0001), and % cyst volume (r = -0.35, P < 0.0001) were inversely related to glomerular filtration rate (GFR). Age-adjusted renal volume (r = 0.42, P < 0.0001), cystic (r = 0.39, P < 0.0001, and % cyst volume (r = 0.41, P < 0.0001) were related with urinary albumin excretion. Conclusion. MR measures of renal and cyst volume are reliable and accurate in patients with ADPKD. ADPKD is characterized by significant cystic involvement that increases with age. Structure (renal and cyst volume) and function (GFR) are inversely related and directly related with the presence of hypertension and urinary albumin excretion in individuals with normal renal function.

AB - Background. Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by gradual renal enlargement and cyst growth prior to loss of renal function. Standard radiographic imaging has not provided the resolution and accuracy necessary to detect small changes in renal volume or to reliably measure renal cyst volumes. The Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP) is longitudinally observing ADPKD individuals using high-resolution magnetic resonance (MR) imaging to determine if change in renal and cyst volumes can be detected over a short period of time, and if they correlate with decline in renal function early in disease. Methods. Standardization studies were conducted in phantoms and four subjects at each participating clinical center. After, in the full-scale protocol, healthy ADPKD individuals 15 to 45 years old with creatinine clearance >70 mL/min underwent standardized MR renal imaging, renal iothalamate clearance, comprehensive clinical evaluation, and determination of 24-hour urinary albumin and electrolyte excretion. Stereology was used from T1-weighted images to quantify renal volume, and region-growing thresholding was used from T2-weighted images to determine cyst volume. Renal structures were evaluated in relation to demographic, clinical, and biochemical variables using means/medians, standard deviations, and Pearson correlations. Results. Reliability coefficients for MR renal and cyst volume measurements in phantoms were 99.9% and 89.2%, respectively. In the full-scale protocol, 241 ADPKD individuals (145 women and 96 men) were enrolled. Total renal, cyst, and % cyst volume were significantly greater in each decade group. Hypertensive individuals demonstrated greater renal, cyst, and % cyst volume than normotensive subjects. Age-adjusted renal (r = -0.31, P < 0.0001), cyst (r = -0.36, P < 0.0001), and % cyst volume (r = -0.35, P < 0.0001) were inversely related to glomerular filtration rate (GFR). Age-adjusted renal volume (r = 0.42, P < 0.0001), cystic (r = 0.39, P < 0.0001, and % cyst volume (r = 0.41, P < 0.0001) were related with urinary albumin excretion. Conclusion. MR measures of renal and cyst volume are reliable and accurate in patients with ADPKD. ADPKD is characterized by significant cystic involvement that increases with age. Structure (renal and cyst volume) and function (GFR) are inversely related and directly related with the presence of hypertension and urinary albumin excretion in individuals with normal renal function.

KW - Autosomal-dominant polycystic kidney disease

KW - Cyst volume

KW - Magnetic resonance imaging

KW - Renal function

KW - Renal volume

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