Renal response to atrial natriuretic factor is modulated by intrarenal angiotensin II

C. J. Schowalter, R. S. Zimmerman, T. R. Schwab, Brooks Sayre Edwards, T. J. Opgenorth, John C Jr. Burnett

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Abstract

The present study in anesthetized dogs (n = 8) was designed to test the hypothesis that intrarenal angiotensin II (ANG II) attenuates the increases in sodium excretion in response to atrial natriuretic factor (ANF). To test this hypothesis, renal hemodynamic and excretory responses to systemically administered ANF (0.3 μg·kg -1·min -1) were assessed in the presence of ANG II infusion into the left kidney (ANG II K) at a nonpressor dose (1.5 ng·kg -1·min -1) and with an infusion of saline into the right kidney, the latter which served as control (CK). During ANF infusion, absolute increases in urinary sodium excretion (Δ + 160.8 ± 44.7 vs. Δ + 369.4 ± 56.9 μeq/min, P < 0.005) and fractional sodium excretion (Δ + 2.55 ± 0.62 vs. Δ + 4.26 ± 0.82%, P < 0.03) were markedly attenuated in the ANG II K compared with CK. Glomerular filtration rate increased only in the CK. Urine osmolality decreased in both the ANG II K and CK. These studies demonstrate an attenuated natriuresis to ANF in the presence of intrarenally infused ANG II, which is associated with a blunted increase in glomerular filtration rate. These studies support the hypothesis that the renal hemodynamic and excretory responses to ANF are modulated by intrarenal ANG II.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume254
Issue number3
StatePublished - 1988

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Atrial Natriuretic Factor
Angiotensin II
Kidney
Sodium
Glomerular Filtration Rate
Hemodynamics
Natriuresis
Osmolar Concentration
Urine
Dogs

ASJC Scopus subject areas

  • Physiology

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Renal response to atrial natriuretic factor is modulated by intrarenal angiotensin II. / Schowalter, C. J.; Zimmerman, R. S.; Schwab, T. R.; Edwards, Brooks Sayre; Opgenorth, T. J.; Burnett, John C Jr.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 254, No. 3, 1988.

Research output: Contribution to journalArticle

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