Renal osteodystrophy

J. T. McCarthy, Rajiv Kumar

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Renal osteodystrophy is a complex disorder which can be divided into five distinct bone histologic subtypes: mild bone disease, hyperparathyroid bone disease, mixed bone disease, osteomalacia, and low-turnover bone disease. Hyperparathyroidism develops in renal failure due to two principal abnormalities: 1,25(OH)2D3 deficiency and hyperphosphatemia. Treatment of these problems is important in order to prevent hyperparathyroidism. Most cases of osteomalacia, mixed bone disease, and low-turnover bone disease are influenced by aluminum status and parathyroid hormone. Aluminum-associated bone disease can be treated with termination of aluminum exposure and/or deferoxamine therapy. Numerous diagnostic pitfalls exist in the evaluation of renal osteodystrophy, and the bone biopsy is extremely important to avoid these problems and plan proper therapy.

Original languageEnglish (US)
Pages (from-to)65-93
Number of pages29
JournalEndocrinology and Metabolism Clinics of North America
Volume19
Issue number1
StatePublished - 1990

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Chronic Kidney Disease-Mineral and Bone Disorder
Bone Diseases
Bone
Aluminum
Osteomalacia
Hyperparathyroidism
Hyperphosphatemia
Bone and Bones
Deferoxamine
Parathyroid Hormone
Biopsy
Renal Insufficiency
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry

Cite this

Renal osteodystrophy. / McCarthy, J. T.; Kumar, Rajiv.

In: Endocrinology and Metabolism Clinics of North America, Vol. 19, No. 1, 1990, p. 65-93.

Research output: Contribution to journalArticle

McCarthy, J. T. ; Kumar, Rajiv. / Renal osteodystrophy. In: Endocrinology and Metabolism Clinics of North America. 1990 ; Vol. 19, No. 1. pp. 65-93.
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