TY - JOUR
T1 - Renal monoclonal immunoglobulin deposition disease
T2 - A report of 64 patients from a single institution
AU - Nasr, Samih H.
AU - Valeri, Anthony M.
AU - Cornell, Lynn D.
AU - Fidler, Mary E.
AU - Sethi, Sanjeev
AU - D'Agati, Vivette D.
AU - Leung, Nelson
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Background and objectives To better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series. Design, setting, participants, & measurements Characteristics of 64 MIDD patients who were seen at Mayo Clinic are provided. Results Of 64 patients with MIDD, 51 had light chain deposition disease, 7 had heavy chain deposition disease, and6had lightandheavy chaindeposition disease.Themean ageatdiagnosis was 56 years,and23patients (36%) were ≤50 years of age. Clinical evidence of dysproteinemia was present in 62 patients (97%), including multiple myeloma in 38 (59%). M-spike was detected on serum protein electrophoresis in 47 (73%). Serum free light chain ratio was abnormal in all 51 patients tested. Presentation included renal insufficiency, proteinuria, hematuria, and hypertension. Nodular mesangial sclerosis was seen in 39 patients (61%). During a median of 25 months of follow-up (range, 1-140) in 56 patients, 32 (57%) had stable/improved renal function, 2 (4%) had worsening renal function, and 22 (39%) progressed to ESRD. The mean renal and patient survivals were 64 and 90 months, respectively. The disease recurred in three of four patients who received a kidney transplant. Conclusions Patients with MIDD generally present at a younger age than those with light chain amyloidosis or light chain cast nephropathy. Serum free light chain ratio is abnormal in all MIDD patients, whereas only three-quarters have abnormal serum protein electrophoresis. The prognosis for MIDD is improving compared with historical controls, likely reflecting earlier detection and improved therapies.
AB - Background and objectives To better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series. Design, setting, participants, & measurements Characteristics of 64 MIDD patients who were seen at Mayo Clinic are provided. Results Of 64 patients with MIDD, 51 had light chain deposition disease, 7 had heavy chain deposition disease, and6had lightandheavy chaindeposition disease.Themean ageatdiagnosis was 56 years,and23patients (36%) were ≤50 years of age. Clinical evidence of dysproteinemia was present in 62 patients (97%), including multiple myeloma in 38 (59%). M-spike was detected on serum protein electrophoresis in 47 (73%). Serum free light chain ratio was abnormal in all 51 patients tested. Presentation included renal insufficiency, proteinuria, hematuria, and hypertension. Nodular mesangial sclerosis was seen in 39 patients (61%). During a median of 25 months of follow-up (range, 1-140) in 56 patients, 32 (57%) had stable/improved renal function, 2 (4%) had worsening renal function, and 22 (39%) progressed to ESRD. The mean renal and patient survivals were 64 and 90 months, respectively. The disease recurred in three of four patients who received a kidney transplant. Conclusions Patients with MIDD generally present at a younger age than those with light chain amyloidosis or light chain cast nephropathy. Serum free light chain ratio is abnormal in all MIDD patients, whereas only three-quarters have abnormal serum protein electrophoresis. The prognosis for MIDD is improving compared with historical controls, likely reflecting earlier detection and improved therapies.
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U2 - 10.2215/CJN.08640811
DO - 10.2215/CJN.08640811
M3 - Article
C2 - 22156754
AN - SCOPUS:84857346852
SN - 1555-9041
VL - 7
SP - 231
EP - 239
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 2
ER -