Renal interstitial pressure in mineralocorticoid escape.

John C Jr. Burnett, J. A. Haas, M. S. Larson

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9 Citations (Scopus)

Abstract

Studies were performed in normal and DOCA-treated rats to determine renal hydrostatic pressures within superficial peritubular capillaries, the vasa recta, and renal interstitium during mineralocorticoid escape to test the hypothesis that mineralocorticoid escape is associated with elevated renal interstitial hydrostatic pressure. Fractional sodium excretion was greater in the DOCA-treated rats (3.20 +/- 0.51%) compared with control rats (1.23 +/- 0.12%) with no difference in glomerular filtration rate and renal blood flow between the two groups. Superficial peritubular capillary hydrostatic pressure (13.4 +/- 0.6 vs. 8.3 +/- 0.3 mmHg), vasa recta hydrostatic pressure (13.8 +/- 0.5 vs. 9.0 +/- 0.4 mmHg), renal interstitial hydrostatic pressure (9.8 +/- 0.4 vs. 4.5 +/- 0.4 mmHg), and arterial pressure (145 +/- 6 vs. 120 +/- 7 mmHg) were greater in the DOCA-treated compared with the control rats. These studies establish that mineralocorticoid escape is characterized by high renal interstitial hydrostatic pressure.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume249
Issue number3 Pt 2
StatePublished - Sep 1985

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Mineralocorticoids
Hydrostatic Pressure
Desoxycorticosterone Acetate
Kidney
Pressure
Rectum
Renal Circulation
Glomerular Filtration Rate
Arterial Pressure
Sodium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Renal interstitial pressure in mineralocorticoid escape. / Burnett, John C Jr.; Haas, J. A.; Larson, M. S.

In: The American journal of physiology, Vol. 249, No. 3 Pt 2, 09.1985.

Research output: Contribution to journalArticle

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