Renal handling of X-ray contrast media imaging and exploration with electron beam CT

Andrew D Rule, Željko Bajzer, Erik L. Ritman, Lilach O Lerman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Physiologic changes in renal hemodynamics and function reflect its role as a regulatory organ in maintaining homeostasis, whereas other alterations may mirror development of renal injury and often precede overt signs of morphologic changes. Furthermore, intrarenal alterations may be discreet and manifest only in the renal cortical, medullary, or papillary zones. The high spatial and temporal resolution of electron-beam computed tomography enables external detection and quantification of cortical, medullary, and papillary tissue density changes following an intravenous bolus injection of X-ray contrast media. These changes reflect flow of contrast media in these renal zones through the successive renal vascular, glomerular, and tubular compartments that can be individually plotted as time-density curves (TDC). Mathematical modeling then allows calculation of unique parameters of renal function from these TDC. This ability to quantify renal regional attributes may not only shed light on the physiologic mechanisms that the kidney controls, but also assist in detecting subtle impairment in its function.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume972
StatePublished - 2002

Fingerprint

Contrast Media
Electron beams
X-Rays
Electrons
Kidney
Imaging techniques
Electron beam computed tomography
X rays
Hemodynamics
Mirrors
Tissue
X Ray Computed Tomography
Imaging
Intravenous Injections
Blood Vessels
Homeostasis
Alteration
Wounds and Injuries

Keywords

  • Blood flow
  • CT
  • Electron beam
  • Kidney
  • Renal function
  • X-ray contrast media

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Renal handling of X-ray contrast media imaging and exploration with electron beam CT. / Rule, Andrew D; Bajzer, Željko; Ritman, Erik L.; Lerman, Lilach O.

In: Annals of the New York Academy of Sciences, Vol. 972, 2002, p. 317-324.

Research output: Contribution to journalArticle

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