TY - JOUR
T1 - Renal Dysfunction following Direct Current Cardioversion of Atrial Fibrillation
T2 - Incidence and Risk Factors
AU - Grüner-Hegge, Nicolai
AU - Kella, Danesh K.
AU - Padmanabhan, Deepak
AU - Deshmukh, Abhishek J.
AU - Mehta, Ramila
AU - Hodge, David
AU - Melduni, Rowlens M.
AU - Greene, Eddie L.
AU - Friedman, Paul A.
N1 - Publisher Copyright:
© 2020 S. Karger AG, Basel. All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Introduction: Emerging data suggest that cardioversion for atrial fibrillation (AF) may be associated with acute kidney injury (AKI). However, limited data are available regarding the incidence and risk factors for AKI after direct current cardioversion (DCCV) of AF. Methods: All patients undergoing DCCV at Mayo Clinic between 2001 and 2012 for AF were prospectively enrolled in a database. All patients with serum creatinine (SCR) values pre- A nd post-cardioversion were reviewed for AKI, defined as a ≥25% decline in eGFR (estimated glomerular filtration rate) from baseline value within 7 days of the DCCV. Results: Of the 6,427 eligible patients, 1,256 (19.5%) patients had pre- A nd post-DCCV SCR available and formed the cohort under study. The mean age was 70.4 (SD 11.7) years, and 67.3% were male. During the study period, 131 (10.4%) patients suffered from AKI following DCCV. AKI was independently associated with inpatient status (OR 26.79; 95% CI 3.69-194.52), CHA2DS2-VASc score (OR 1.25; 95% CI 1.11-1.41), prior use of diuretics (OR 1.59; 95% CI 1.03-2.46), and absence of CKD (OR 1.61; 95% CI 1.04-2.49), and was independent of the success of the DCCV. None of the patients required acute dialysis during the study outcome period. Conclusion: AKI following DCCV of AF is common, self-limited, and without the need for replacement therapies.
AB - Introduction: Emerging data suggest that cardioversion for atrial fibrillation (AF) may be associated with acute kidney injury (AKI). However, limited data are available regarding the incidence and risk factors for AKI after direct current cardioversion (DCCV) of AF. Methods: All patients undergoing DCCV at Mayo Clinic between 2001 and 2012 for AF were prospectively enrolled in a database. All patients with serum creatinine (SCR) values pre- A nd post-cardioversion were reviewed for AKI, defined as a ≥25% decline in eGFR (estimated glomerular filtration rate) from baseline value within 7 days of the DCCV. Results: Of the 6,427 eligible patients, 1,256 (19.5%) patients had pre- A nd post-DCCV SCR available and formed the cohort under study. The mean age was 70.4 (SD 11.7) years, and 67.3% were male. During the study period, 131 (10.4%) patients suffered from AKI following DCCV. AKI was independently associated with inpatient status (OR 26.79; 95% CI 3.69-194.52), CHA2DS2-VASc score (OR 1.25; 95% CI 1.11-1.41), prior use of diuretics (OR 1.59; 95% CI 1.03-2.46), and absence of CKD (OR 1.61; 95% CI 1.04-2.49), and was independent of the success of the DCCV. None of the patients required acute dialysis during the study outcome period. Conclusion: AKI following DCCV of AF is common, self-limited, and without the need for replacement therapies.
KW - Acute kidney injury
KW - Atrial fibrillation
KW - Direct current cardioversion
UR - http://www.scopus.com/inward/record.url?scp=85097830410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097830410&partnerID=8YFLogxK
U2 - 10.1159/000507566
DO - 10.1159/000507566
M3 - Article
C2 - 33296908
AN - SCOPUS:85097830410
SN - 1664-3828
VL - 11
SP - 27
EP - 32
JO - CardioRenal Medicine
JF - CardioRenal Medicine
IS - 1
ER -