Renal cortical neoplasms in long term survivors of solid organ transplantation

Michael Torbenson, Jianzhou Wang, Larry Nichols, Parmjeet Randhawa, Michael A. Nalesnik

Research output: Contribution to journalArticle

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Abstract

Background. Renal cortical neoplasms have been reported after organ transplantation, but the level of risk as well as the histological features are poorly defined. Methods. A retrospective autopsy-based study was performed to evaluate renal neoplasms occurring in patients who underwent solid organ transplantation, died, and received an autopsy from 1981 to 1997 (383 liver, 125 heart, 52 lung, 39 heart/lung, 98 kidney, 4 bowel). Patients were divided into those with short (less than 101 days), medium (101 days to 5 years), and long-term survival (more than 5 years). The control group consisted of hospital autopsies on nontransplanted patients from the odd- numbered years, 1983 through 1997. Results. Renal cortical neoplasms were identified in 32/1325 of nontransplanted patients and 15/701 transplanted patients. In transplanted patients, neoplasms were identified in 14 native and 1 allograft kidney: 2/391 in short-term survivors, 3/234 in medium, and 10/76 in long term survivors. While transplant patients with short and medium length survival had no increased risk for neoplasms, patients with long-term survival showed a 9-fold increase in cortical neoplasms. Transplant patients with neoplasms averaged 47 years of age at death, significantly younger than the average age of 70 for nontransplanted control patients with renal neoplasms. The neoplasms in transplanted patients were all tubulopapillary, except for one clear cell neoplasm and ranged in size from 0.1 to 2 cm. Conclusions. Long-term survivors of solid organ transplants have an 9-fold increased risk of developing tubulopapillary renal cortical neoplasms.

Original languageEnglish (US)
Pages (from-to)864-868
Number of pages5
JournalTransplantation
Volume69
Issue number5
StatePublished - Mar 15 2000
Externally publishedYes

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Kidney Neoplasms
Organ Transplantation
Survivors
Autopsy
Neoplasms
Transplants
Survival
Kidney
Lung
Allografts

ASJC Scopus subject areas

  • Transplantation

Cite this

Torbenson, M., Wang, J., Nichols, L., Randhawa, P., & Nalesnik, M. A. (2000). Renal cortical neoplasms in long term survivors of solid organ transplantation. Transplantation, 69(5), 864-868.

Renal cortical neoplasms in long term survivors of solid organ transplantation. / Torbenson, Michael; Wang, Jianzhou; Nichols, Larry; Randhawa, Parmjeet; Nalesnik, Michael A.

In: Transplantation, Vol. 69, No. 5, 15.03.2000, p. 864-868.

Research output: Contribution to journalArticle

Torbenson, M, Wang, J, Nichols, L, Randhawa, P & Nalesnik, MA 2000, 'Renal cortical neoplasms in long term survivors of solid organ transplantation', Transplantation, vol. 69, no. 5, pp. 864-868.
Torbenson M, Wang J, Nichols L, Randhawa P, Nalesnik MA. Renal cortical neoplasms in long term survivors of solid organ transplantation. Transplantation. 2000 Mar 15;69(5):864-868.
Torbenson, Michael ; Wang, Jianzhou ; Nichols, Larry ; Randhawa, Parmjeet ; Nalesnik, Michael A. / Renal cortical neoplasms in long term survivors of solid organ transplantation. In: Transplantation. 2000 ; Vol. 69, No. 5. pp. 864-868.
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abstract = "Background. Renal cortical neoplasms have been reported after organ transplantation, but the level of risk as well as the histological features are poorly defined. Methods. A retrospective autopsy-based study was performed to evaluate renal neoplasms occurring in patients who underwent solid organ transplantation, died, and received an autopsy from 1981 to 1997 (383 liver, 125 heart, 52 lung, 39 heart/lung, 98 kidney, 4 bowel). Patients were divided into those with short (less than 101 days), medium (101 days to 5 years), and long-term survival (more than 5 years). The control group consisted of hospital autopsies on nontransplanted patients from the odd- numbered years, 1983 through 1997. Results. Renal cortical neoplasms were identified in 32/1325 of nontransplanted patients and 15/701 transplanted patients. In transplanted patients, neoplasms were identified in 14 native and 1 allograft kidney: 2/391 in short-term survivors, 3/234 in medium, and 10/76 in long term survivors. While transplant patients with short and medium length survival had no increased risk for neoplasms, patients with long-term survival showed a 9-fold increase in cortical neoplasms. Transplant patients with neoplasms averaged 47 years of age at death, significantly younger than the average age of 70 for nontransplanted control patients with renal neoplasms. The neoplasms in transplanted patients were all tubulopapillary, except for one clear cell neoplasm and ranged in size from 0.1 to 2 cm. Conclusions. Long-term survivors of solid organ transplants have an 9-fold increased risk of developing tubulopapillary renal cortical neoplasms.",
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N2 - Background. Renal cortical neoplasms have been reported after organ transplantation, but the level of risk as well as the histological features are poorly defined. Methods. A retrospective autopsy-based study was performed to evaluate renal neoplasms occurring in patients who underwent solid organ transplantation, died, and received an autopsy from 1981 to 1997 (383 liver, 125 heart, 52 lung, 39 heart/lung, 98 kidney, 4 bowel). Patients were divided into those with short (less than 101 days), medium (101 days to 5 years), and long-term survival (more than 5 years). The control group consisted of hospital autopsies on nontransplanted patients from the odd- numbered years, 1983 through 1997. Results. Renal cortical neoplasms were identified in 32/1325 of nontransplanted patients and 15/701 transplanted patients. In transplanted patients, neoplasms were identified in 14 native and 1 allograft kidney: 2/391 in short-term survivors, 3/234 in medium, and 10/76 in long term survivors. While transplant patients with short and medium length survival had no increased risk for neoplasms, patients with long-term survival showed a 9-fold increase in cortical neoplasms. Transplant patients with neoplasms averaged 47 years of age at death, significantly younger than the average age of 70 for nontransplanted control patients with renal neoplasms. The neoplasms in transplanted patients were all tubulopapillary, except for one clear cell neoplasm and ranged in size from 0.1 to 2 cm. Conclusions. Long-term survivors of solid organ transplants have an 9-fold increased risk of developing tubulopapillary renal cortical neoplasms.

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