Renal blood flow in hypercholesterolemic pigs is increased by chronic antioxidant treatment

F. De Nigris, M. P. Demontis, Martin G Rodriguez-Porcel, V. Anania, Lilach O Lerman, C. Napoli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Oxygen radical species can influence vascular tone, and antioxidants may have hemodynamic and vascular effects. To date, the vascular effects of chronic intervention with a combination of antioxidant vitamins E and C on renal blood flow (RBF) in hypercholesterolemia (which increases oxidative stress) have not been fully defined. The aim of this intervention study was to explore the involvement of increased oxidative stress in pig RBF disturbance by using chronic dietary antioxidant vitamin intervention. Responses of RBF to the acetylcholine (Ach) were measured in vivo using electron beam computed tomography (EBCT). Acetylcholine significantly increased RBF in normal and hypercholesterolemic + vitamins (P < 0.05 for both), but not in hypercholesterolemic pigs (P = 0.1). In normocholesterolemic + vitamins pigs, Ach infusion did not induce any further increase in RBF, but RBF was similar to that observed in normal and hypercholesterolemic + vitamins under the same conditions, and tended to be higher than in hypercholesterolemic pigs (P = 0.06). Thus, antioxidants improve RBF in hypercholesterolemic pigs and this effect may help to prevent renal diseases and hypertension in animals.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume26
Issue number2
DOIs
StatePublished - Apr 2003

Fingerprint

Renal Circulation
blood flow
Swine
Antioxidants
kidneys
antioxidants
swine
Vitamins
acetylcholine
blood vessels
Acetylcholine
Blood Vessels
vitamins
Oxidative Stress
oxidative stress
bioflavonoids
Renal Hypertension
X Ray Computed Tomography
hypercholesterolemia
hemodynamics

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Renal blood flow in hypercholesterolemic pigs is increased by chronic antioxidant treatment. / De Nigris, F.; Demontis, M. P.; Rodriguez-Porcel, Martin G; Anania, V.; Lerman, Lilach O; Napoli, C.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 26, No. 2, 04.2003, p. 113-116.

Research output: Contribution to journalArticle

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