Renal Arterial Disease and Hypertension

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Renal artery disease produces a spectrum of progressive clinical manifestations ranging from minor degrees of hypertension to circulatory congestion and kidney failure. Moderate reductions in renal blood flow do not induce tissue hypoxia or damage, making medical therapy for renovascular hypertension feasible. Several prospective trials indicate that optimized medical therapy using agents that block the renin-angiotensin system should be the initial management. Evidence of progressive disease and/or treatment failure should allow recognition of high-risk subsets that benefit from renal revascularization. Severe reductions in kidney blood flow ultimately activate inflammatory pathways that do not reverse with restoring blood flow alone.

Original languageEnglish (US)
Pages (from-to)65-79
Number of pages15
JournalMedical Clinics of North America
Volume101
Issue number1
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Angiotensin
  • Hypertension
  • Ischemic nephropathy
  • Kidney
  • Renal artery stenosis
  • Renovascular

ASJC Scopus subject areas

  • Medicine(all)

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