Renal and humoral pathophysiological actions of angiotensin II in congestive heart failure

Zaur Mirzoyev, Nandan S. Anavekar, Horng Haur Chen

Research output: Contribution to journalArticle

Abstract

The renin-angiotensin-aldosterone axis is an integral component linking the renal-humoral system to the cardiovascular system. It is involved in the normal control of blood pressure and intravascular volume. Its activity is also enhanced in pathologic states, namely congestive heart failure, in which stimulation of the axis leads to further deleterious effects on the heart. The well-established dogma that the renin-angiotensin-aldosterone system (RAAS) is a linear cascade is evolving into a vision of this system as a more complex process. It is now known that angiotensin has several subtypes. Each subtype is a ligand at several receptor subtypes and these interactions are not mutually exclusive. The aim of this review is to discuss the different angiotensin subtypes, their receptor interactions and their pathophysiological roles in humoral and renal functions in congestive heart failure. In addition, we will also review the different therapeutic approaches that interrupt the RAAS and the evidence that supports their utility in congestive heart failure (CHF).

Original languageEnglish (US)
Pages (from-to)129-139
Number of pages11
JournalDrugs of Today
Volume41
Issue number2
DOIs
StatePublished - Feb 2005

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Angiotensins
Angiotensin II
Heart Failure
Renin-Angiotensin System
Kidney
Cardiovascular System
Aldosterone
Renin
Blood Pressure
Ligands
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Renal and humoral pathophysiological actions of angiotensin II in congestive heart failure. / Mirzoyev, Zaur; Anavekar, Nandan S.; Chen, Horng Haur.

In: Drugs of Today, Vol. 41, No. 2, 02.2005, p. 129-139.

Research output: Contribution to journalArticle

Mirzoyev, Zaur ; Anavekar, Nandan S. ; Chen, Horng Haur. / Renal and humoral pathophysiological actions of angiotensin II in congestive heart failure. In: Drugs of Today. 2005 ; Vol. 41, No. 2. pp. 129-139.
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