Renal Amyloidosis

Nasreen Mohamed; Samih H. Nasr

doi:10.1016/j.path.2014.04.006

Renal Amyloidosis

Nasreen Mohamed, Samih H. Nasr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.

Original language	English (US)
Pages (from-to)	409-425
Number of pages	17
Journal	Surgical Pathology Clinics
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/j.path.2014.04.006
State	Published - Sep 2014

Keywords

AA amyloidosis
AL amyloidosis
Amyloid types
Amyloidosis
Laser microdissection and mass spectrometry
Renal biopsy

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2014.04.006

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title = "Renal Amyloidosis",

abstract = "Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.",

keywords = "AA amyloidosis, AL amyloidosis, Amyloid types, Amyloidosis, Laser microdissection and mass spectrometry, Renal biopsy",

author = "Nasreen Mohamed and Nasr, {Samih H.}",

year = "2014",

month = sep,

doi = "10.1016/j.path.2014.04.006",

language = "English (US)",

volume = "7",

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TY - JOUR

T1 - Renal Amyloidosis

AU - Mohamed, Nasreen

AU - Nasr, Samih H.

PY - 2014/9

Y1 - 2014/9

N2 - Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.

AB - Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.

KW - AA amyloidosis

KW - AL amyloidosis

KW - Amyloid types

KW - Amyloidosis

KW - Laser microdissection and mass spectrometry

KW - Renal biopsy

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DO - 10.1016/j.path.2014.04.006

M3 - Review article

AN - SCOPUS:84906087962

SN - 1875-9181

VL - 7

SP - 409

EP - 425

JO - Surgical Pathology Clinics

JF - Surgical Pathology Clinics

IS - 3

ER -

Renal Amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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