Renal Amyloidosis

Nasreen Mohamed, Samih H. Nasr

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Amyloidosis is an uncommon group of diseases in which soluble proteins aggregate and deposit extracellularly in tissue as insoluble fibrils, leading to tissue destruction and progressive organ dysfunction. More than 25 proteins have been identified as amyloid precursor proteins. Amyloid fibrils have a characteristic appearance on ultrastructural examination and generate anomalous colors under polarized light. Amyloidosis can be systemic or localized. The kidney is a prime site for amyloid deposition. Immunofluorescence, immunoperoxidase, and more recently laser microdissection and mass spectrometry are important tools used in the typing of renal amyloidosis.

Original languageEnglish (US)
Pages (from-to)409-425
Number of pages17
JournalSurgical Pathology Clinics
Volume7
Issue number3
DOIs
StatePublished - Sep 2014

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Keywords

  • AA amyloidosis
  • AL amyloidosis
  • Amyloid types
  • Amyloidosis
  • Laser microdissection and mass spectrometry
  • Renal biopsy

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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