Remote ischemic preconditioning for elective endovascular intracranial aneurysm repair: a feasibility study

Seyed Mohammad Seyedsaadat, Leonardo Rangel Castilla, Giuseppe Lanzino, Harry J. Cloft, Daniel J. Blezek, Amy Theiler, Ramanathan D Kadirvel, Waleed Brinjikji, David F Kallmes

Research output: Contribution to journalArticle

Abstract

Objectives: Remote ischemic preconditioning has been proposed as a possible potential treatment for ischemic stroke. However, neuroprotective benefits of the pre-procedural administration of remote ischemic preconditioning have not been investigated in patients undergoing an elective endovascular intracranial aneurysm repair procedure. This study investigated the safety and feasibility of remote ischemic preconditioning in patients with an unruptured intracranial aneurysm who undergo elective endovascular treatment. Methods: In this single-center prospective study, patients with an unruptured intracranial aneurysm undergoing elective endovascular treatment with flow diverters or coiling were recruited. Patients received three intermittent cycles of 5 minutes arm ischemia followed by reperfusion using manual blood cuff inflation/deflation less than 5 hours prior to endovascular treatment. Patients were monitored and followed up for remote ischemic preconditioning-related adverse events and ischemic brain lesions by diffusion-weighted magnetic resonance imaging within 48 hours following endovascular treatment. Results: A total of seven patients aged 60 ± 5 years with an unruptured intracranial aneurysm successfully completed a total of 21 sessions of remote ischemic preconditioning and the required procedures. Except for two patients who developed skin petechiae over their arms, no other serious procedure-related adverse events were observed as a result of the remote ischemic preconditioning procedure. On follow-up diffusion-weighted magnetic resonance imaging, a total of 19 ischemic brain lesions with a median (interquartile range) volume of 245 (61–466) mm 3 were found in four out of seven patients. Conclusions: The application of remote ischemic preconditioning prior to endovascular intracranial aneurysm repair was well tolerated, safe and clinically feasible. Larger sham-controlled clinical trials are required to determine the safety and efficacy of this therapeutic strategy in mitigating ischemic damage following endovascular treatment of intracranial aneurysms.

Original languageEnglish (US)
JournalNeuroradiology Journal
DOIs
StatePublished - Jan 1 2019

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Ischemic Preconditioning
Intracranial Aneurysm
Feasibility Studies
Diffusion Magnetic Resonance Imaging
Therapeutics
Safety
Purpura
Controlled Clinical Trials
Economic Inflation
Brain
Reperfusion
Ischemia
Stroke
Prospective Studies
Skin

Keywords

  • aneurysm
  • intracranial aneurysm
  • ischemic preconditioning
  • magnetic resonance imaging
  • Preconditioning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Remote ischemic preconditioning for elective endovascular intracranial aneurysm repair : a feasibility study. / Mohammad Seyedsaadat, Seyed; Rangel Castilla, Leonardo; Lanzino, Giuseppe; Cloft, Harry J.; Blezek, Daniel J.; Theiler, Amy; Kadirvel, Ramanathan D; Brinjikji, Waleed; Kallmes, David F.

In: Neuroradiology Journal, 01.01.2019.

Research output: Contribution to journalArticle

Mohammad Seyedsaadat, Seyed ; Rangel Castilla, Leonardo ; Lanzino, Giuseppe ; Cloft, Harry J. ; Blezek, Daniel J. ; Theiler, Amy ; Kadirvel, Ramanathan D ; Brinjikji, Waleed ; Kallmes, David F. / Remote ischemic preconditioning for elective endovascular intracranial aneurysm repair : a feasibility study. In: Neuroradiology Journal. 2019.
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AU - Rangel Castilla, Leonardo

AU - Lanzino, Giuseppe

AU - Cloft, Harry J.

AU - Blezek, Daniel J.

AU - Theiler, Amy

AU - Kadirvel, Ramanathan D

AU - Brinjikji, Waleed

AU - Kallmes, David F

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