Remodeling and reparation of the cardiovascular system

Karl T. Weber, Piero Anversa, Paul W. Armstrong, Christian G. Brilla, John C. Burnett, John M. Cruickshank, Richard B. Devereux, Thomas D. Giles, Niels Korsgaard, Carl V. Leier, Frederick A.O. Mendelsohn, Wolfgang H. Motz, Michael J. Mulvany, Bodo E. Strauer

Research output: Contribution to journalReview article

290 Scopus citations

Abstract

Growth or altered metabolism of nonmyocyte cells (cardiac fibroblasts, vascular smooth muscle and endothelial cells) alters myocardial and vascular structure (remodeling) and function. However, the precise roles of circulating and locally generated factors such as angiotensin II, aldosterone and endothelin that regulate growth and metabolism of nonmyocyte cells have yet to be fully elucidated. Trials of pharmacologic therapy aimed at preventing structural remodeling and repairing altered myocardial structure to or toward normal in the setting of hypertension, heart failure and diabetes are reviewed. It is proposed that these are therapeutic goals that may reduce cardiovascular morbidity and mortality. Although this hypothesis remains unproved the primary goal of therapy should be to preserve or restore tissue structure and function.

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalJournal of the American College of Cardiology
Volume20
Issue number1
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Weber, K. T., Anversa, P., Armstrong, P. W., Brilla, C. G., Burnett, J. C., Cruickshank, J. M., Devereux, R. B., Giles, T. D., Korsgaard, N., Leier, C. V., Mendelsohn, F. A. O., Motz, W. H., Mulvany, M. J., & Strauer, B. E. (1992). Remodeling and reparation of the cardiovascular system. Journal of the American College of Cardiology, 20(1), 3-16. https://doi.org/10.1016/0735-1097(92)90130-F