Remission of disseminated cancer after systemic oncolytic virotherapy

Stephen J. Russell; Mark J. Federspiel; Kah Whye Peng; Caili Tong; David Dingli; William G. Morice; Val Lowe; Michael K. O'Connor; Robert A. Kyle; Nelson Leung; Francis K. Buadi; S. Vincent Rajkumar; Morie A. Gertz; Martha Q. Lacy; Angela Dispenzieri

doi:10.1016/j.mayocp.2014.04.003

Remission of disseminated cancer after systemic oncolytic virotherapy

Stephen J. Russell, Mark J. Federspiel, Kah Whye Peng, Caili Tong, David Dingli, William G. Morice, Val Lowe, Michael K. O'Connor, Robert A. Kyle, Nelson Leung, Francis K. Buadi, S. Vincent Rajkumar, Morie A. Gertz, Martha Q. Lacy, Angela Dispenzieri

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 10¹¹ TCID₅₀ (50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone-marrow plasmacytosis. Further, one patient experienced durable complete remission at all disease sites. Tumor targeting was clearly documented by NIS-mediated radioiodine uptake in virus-infected plasmacytomas. Toxicities resolved with in the first week after therapy. Oncolytic viruses offer a promising new modality for the targeted infection and destruction of disseminated cancer.

Original language	English (US)
Pages (from-to)	926-933
Number of pages	8
Journal	Mayo Clinic proceedings
Volume	89
Issue number	7
DOIs	https://doi.org/10.1016/j.mayocp.2014.04.003
State	Published - Jul 2014

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Medicine(all)

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Russell, S. J., Federspiel, M. J., Peng, K. W., Tong, C., Dingli, D., Morice, W. G., Lowe, V., O'Connor, M. K., Kyle, R. A., Leung, N., Buadi, F. K., Rajkumar, S. V., Gertz, M. A., Lacy, M. Q., & Dispenzieri, A. (2014). Remission of disseminated cancer after systemic oncolytic virotherapy. Mayo Clinic proceedings, 89(7), 926-933. https://doi.org/10.1016/j.mayocp.2014.04.003

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title = "Remission of disseminated cancer after systemic oncolytic virotherapy",

abstract = "MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 1011 TCID50 (50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone-marrow plasmacytosis. Further, one patient experienced durable complete remission at all disease sites. Tumor targeting was clearly documented by NIS-mediated radioiodine uptake in virus-infected plasmacytomas. Toxicities resolved with in the first week after therapy. Oncolytic viruses offer a promising new modality for the targeted infection and destruction of disseminated cancer.",

author = "Russell, {Stephen J.} and Federspiel, {Mark J.} and Peng, {Kah Whye} and Caili Tong and David Dingli and Morice, {William G.} and Val Lowe and O'Connor, {Michael K.} and Kyle, {Robert A.} and Nelson Leung and Buadi, {Francis K.} and Rajkumar, {S. Vincent} and Gertz, {Morie A.} and Lacy, {Martha Q.} and Angela Dispenzieri",

year = "2014",

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AU - Tong, Caili

AU - Dingli, David

AU - Morice, William G.

AU - Lowe, Val

AU - O'Connor, Michael K.

AU - Kyle, Robert A.

AU - Leung, Nelson

AU - Buadi, Francis K.

AU - Rajkumar, S. Vincent

AU - Gertz, Morie A.

AU - Lacy, Martha Q.

AU - Dispenzieri, Angela

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AB - MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 1011 TCID50 (50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone-marrow plasmacytosis. Further, one patient experienced durable complete remission at all disease sites. Tumor targeting was clearly documented by NIS-mediated radioiodine uptake in virus-infected plasmacytomas. Toxicities resolved with in the first week after therapy. Oncolytic viruses offer a promising new modality for the targeted infection and destruction of disseminated cancer.

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Remission of disseminated cancer after systemic oncolytic virotherapy

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