TY - CHAP
T1 - REM sleep behavior disorder
T2 - Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions
AU - Boeve, Bradley F.
PY - 2010/1
Y1 - 2010/1
N2 - Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/- dream enactment behavior during REM sleep. Management with counseling and pharmacologic measures is usually straightforward and effective. In this review, the terminology, clinical and polysomnographic features, demographic and epidemiologic features, diagnostic criteria, differential diagnosis, and management strategies are discussed. Recent data on the suspected pathophysiologic mechanisms of RBD are also reviewed. The literature and our institutional experience on RBD are next discussed, with an emphasis on the RBD-neurodegenerative disease association and particularly the RBD-synucleinopathy association. Several issues relating to evolving concepts, controversies, and future directions are then reviewed, with an emphasis on idiopathic RBD representing an early feature of a neurodegenerative disease and particularly an evolving synucleinopathy. Planning for future therapies that impact patients with idiopathic RBD is reviewed in detail.
AB - Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/- dream enactment behavior during REM sleep. Management with counseling and pharmacologic measures is usually straightforward and effective. In this review, the terminology, clinical and polysomnographic features, demographic and epidemiologic features, diagnostic criteria, differential diagnosis, and management strategies are discussed. Recent data on the suspected pathophysiologic mechanisms of RBD are also reviewed. The literature and our institutional experience on RBD are next discussed, with an emphasis on the RBD-neurodegenerative disease association and particularly the RBD-synucleinopathy association. Several issues relating to evolving concepts, controversies, and future directions are then reviewed, with an emphasis on idiopathic RBD representing an early feature of a neurodegenerative disease and particularly an evolving synucleinopathy. Planning for future therapies that impact patients with idiopathic RBD is reviewed in detail.
KW - Neurodegenerative disease
KW - Parasomnia
KW - REM sleep behavior disorder
KW - Synucleinopathy
UR - http://www.scopus.com/inward/record.url?scp=77949903007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949903007&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05115.x
DO - 10.1111/j.1749-6632.2009.05115.x
M3 - Chapter
C2 - 20146689
AN - SCOPUS:77949903007
SN - 9781573317801
T3 - Annals of the New York Academy of Sciences
SP - 15
EP - 54
BT - The Year in Neurology 2
PB - Blackwell Publishing Inc.
ER -