REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions

Research output: Chapter in Book/Report/Conference proceedingChapter

367 Scopus citations

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/- dream enactment behavior during REM sleep. Management with counseling and pharmacologic measures is usually straightforward and effective. In this review, the terminology, clinical and polysomnographic features, demographic and epidemiologic features, diagnostic criteria, differential diagnosis, and management strategies are discussed. Recent data on the suspected pathophysiologic mechanisms of RBD are also reviewed. The literature and our institutional experience on RBD are next discussed, with an emphasis on the RBD-neurodegenerative disease association and particularly the RBD-synucleinopathy association. Several issues relating to evolving concepts, controversies, and future directions are then reviewed, with an emphasis on idiopathic RBD representing an early feature of a neurodegenerative disease and particularly an evolving synucleinopathy. Planning for future therapies that impact patients with idiopathic RBD is reviewed in detail.

Original languageEnglish (US)
Title of host publicationThe Year in Neurology 2
PublisherBlackwell Publishing Inc.
Pages15-54
Number of pages40
ISBN (Print)9781573317801
DOIs
StatePublished - Jan 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1184
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Neurodegenerative disease
  • Parasomnia
  • REM sleep behavior disorder
  • Synucleinopathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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