Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

R. C. Ma; J. H. Szurszewski

doi:10.1016/0196-9781(95)02064-0

Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

R. C. Ma, J. H. Szurszewski

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.

Original language	English (US)
Pages (from-to)	161-170
Number of pages	10
Journal	Peptides
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0196-9781(95)02064-0
State	Published - 1996

Keywords

Calcitonin gene-related peptide
Capsaicin
Dorsal root ganglion
Dynorphin
Enkephalin
Guinea pig
Inferior mesenteric ganglion
Neurotensin
Prevertebral ganglia

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(95)02064-0

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title = "Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion",

abstract = "Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.",

keywords = "Calcitonin gene-related peptide, Capsaicin, Dorsal root ganglion, Dynorphin, Enkephalin, Guinea pig, Inferior mesenteric ganglion, Neurotensin, Prevertebral ganglia",

author = "Ma, {R. C.} and Szurszewski, {J. H.}",

note = "Funding Information: This work was supported by National Institutes of Health grant DK 17632. The authors are indebted to Jan Applequist, Philip Schmalz, and William Anding for expert technical assistance.",

year = "1996",

doi = "10.1016/0196-9781(95)02064-0",

language = "English (US)",

volume = "17",

pages = "161--170",

journal = "Peptides",

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T1 - Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

AU - Ma, R. C.

AU - Szurszewski, J. H.

N1 - Funding Information: This work was supported by National Institutes of Health grant DK 17632. The authors are indebted to Jan Applequist, Philip Schmalz, and William Anding for expert technical assistance.

PY - 1996

Y1 - 1996

N2 - Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.

AB - Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.

KW - Calcitonin gene-related peptide

KW - Capsaicin

KW - Dorsal root ganglion

KW - Dynorphin

KW - Enkephalin

KW - Guinea pig

KW - Inferior mesenteric ganglion

KW - Neurotensin

KW - Prevertebral ganglia

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Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

Abstract

Keywords

ASJC Scopus subject areas

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