Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

R. C. Ma, J. H. Szurszewski

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalPeptides
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • Calcitonin gene-related peptide
  • Capsaicin
  • Dorsal root ganglion
  • Dynorphin
  • Enkephalin
  • Guinea pig
  • Inferior mesenteric ganglion
  • Neurotensin
  • Prevertebral ganglia

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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