Relative Motion of the Connective Tissue in Carpal Tunnel Syndrome: The Relation with Disease Severity and Clinical Outcome

Verena J.M.M. Schrier, Stefanie Evers, Jennifer R. Geske, Walter K. Kremers, Hector R. Villarraga, Ruud W. Selles, Steven E.R. Hovius, Russell Gelfman, Peter C. Amadio

Research output: Contribution to journalArticle

Abstract

Excursion of the median nerve and the surrounding subsynovial connective tissue (SSCT) is diminished in patients with carpal tunnel syndrome (CTS). This study sought to determine if SSCT excursion could be utilized to predict surgical outcome. Idiopathic CTS patients were reviewed with ultrasound and electrodiagnostic tests at baseline. A speckle tracking algorithm was used to determine SSCT relative to tendon motion (shear index). Analysis of variance tests were used to compare SSCT motion with disease severity at baseline. Adjusted linear regressions were used to test the association with patient-reported outcome. A total of 90 CTS patients were analyzed and found to have an average shear index of 79% (95% confidence interval: 76.3%–81.6%). SSCT motion was lower in CTS patients with increasing electrophysiological severity (p = 0.0475). There was no significant association of pre-operative SSCT motion with symptomatic improvement (p = 0.268). Overall, SSCT motion is decreased in CTS patients, but exhibits limited correlation with clinical severity.

Original languageEnglish (US)
Pages (from-to)2236-2244
Number of pages9
JournalUltrasound in Medicine and Biology
Volume46
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Carpal tunnel syndrome
  • Dynamic ultrasound
  • Nerve mobility

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Relative Motion of the Connective Tissue in Carpal Tunnel Syndrome: The Relation with Disease Severity and Clinical Outcome'. Together they form a unique fingerprint.

  • Cite this