Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank

Warren W. Barker, Cheryl A. Luis, Alice Kashuba, Mercy Luis, Dylan G. Harwood, David Loewenstein, Carol Waters, Pat Jimison, Eugene Shepherd, Steven Sevush, Neil Graff-Radford, Douglas Newland, Murray Todd, Bayard Miller, Michael Gold, Kenneth Heilman, Leilani Doty, Ira Goodman, Bruce Robinson, Gary PearlDennis Dickson, Ranjan Duara

Research output: Contribution to journalArticle

398 Scopus citations

Abstract

Alzheimer disease (AD) is the most common dementing illness in the elderly, but there is equivocal evidence regarding the frequency of other disorders such as Lewy body disease (LBD), vascular dementia (VaD), frontotemporal dementia (FTD), and hippocampal sclerosis (HS). This ambiguity may be related to factors such as the age and gender of subjects with dementia. Therefore, the objective of this study was to calculate the relative frequencies of AD, LBD, VaD, FTD, and HS among 382 subjects with dementia from the State of Florida Brain Bank and to study the effect of age and gender on these frequencies. AD was the most frequent pathologic finding (77%), followed by LBD (26%), VaD (18%), HS (13%), and FTD (5%). Mixed pathology was common: Concomitant AD was present in 66% of LBD patients, 77% of VaD patients, and 66% of HS patients. The relative frequency of VaD increased with age, whereas the relative frequencies of FTD and LBD declined with age. Males were overrepresented among those with LBD, whereas females were overrepresented among AD subjects with onset age over 70 years. These estimates of the a priori probabilities of dementing disorders have implications for clinicians and researchers.

Original languageEnglish (US)
Pages (from-to)203-212
Number of pages10
JournalAlzheimer disease and associated disorders
Volume16
Issue number4
DOIs
StatePublished - Oct 2002

Keywords

  • Alzheimer disease
  • Autopsy
  • Dementia
  • Lewy body
  • Vascular Dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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    Barker, W. W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., Waters, C., Jimison, P., Shepherd, E., Sevush, S., Graff-Radford, N., Newland, D., Todd, M., Miller, B., Gold, M., Heilman, K., Doty, L., Goodman, I., Robinson, B., ... Duara, R. (2002). Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer disease and associated disorders, 16(4), 203-212. https://doi.org/10.1097/00002093-200210000-00001