TY - JOUR
T1 - Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease
AU - Kwiatek-Majkusiak, Jolanta
AU - Dickson, Dennis W.
AU - Tacik, Paweł
AU - Aoki, Naoya
AU - Tomasiuk, Ryszard
AU - Koziorowski, Dariusz
AU - Friedman, Andrzej
N1 - Publisher Copyright:
© 2015 by Polish Neuroscience Society-PTBUN.
PY - 2015
Y1 - 2015
N2 - Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p<0.001, p=0.025, p=0.029). A significant correlation was also found between the concentration of L-ferritin and neuronal loss (p=0.0026). These findings indicate an important role of ferritin light chains in neurodegeneration, that is linked to chronic inflammation processes and the associated activation of the microglia rich of L chains.
AB - Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p<0.001, p=0.025, p=0.029). A significant correlation was also found between the concentration of L-ferritin and neuronal loss (p=0.0026). These findings indicate an important role of ferritin light chains in neurodegeneration, that is linked to chronic inflammation processes and the associated activation of the microglia rich of L chains.
KW - Alzheimer’s disease
KW - H and L chains of ferritin
KW - Hippocampus
KW - Neuronal loss
KW - Senile plaques
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M3 - Article
C2 - 26994418
AN - SCOPUS:84955268624
SN - 0065-1400
VL - 75
SP - 391
EP - 398
JO - Acta Neurobiologiae Experimentalis
JF - Acta Neurobiologiae Experimentalis
IS - 4
ER -