Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease

Jolanta Kwiatek-Majkusiak, Dennis W Dickson, Paweł Tacik, Naoya Aoki, Ryszard Tomasiuk, Dariusz Koziorowski, Andrzej Friedman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalActa Neurobiologiae Experimentalis
Volume75
Issue number4
StatePublished - 2015

Keywords

  • Alzheimer’s disease
  • H and L chains of ferritin
  • Hippocampus
  • Neuronal loss
  • Senile plaques

ASJC Scopus subject areas

  • Neuroscience(all)

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