Relationships between the human pepsinogen DNA and protein polymorphisms

R. T. Taggart; I. M. Samloff; L. J. Raffel; A. Graham; C. Cass; G. M. Petersen; J. I. Rotter; M. H. Skolnick; C. E. Schwartz; G. I. Bell

Relationships between the human pepsinogen DNA and protein polymorphisms

R. T. Taggart, I. M. Samloff, L. J. Raffel, A. Graham, C. Cass, G. M. Petersen, J. I. Rotter, M. H. Skolnick, C. E. Schwartz, G. I. Bell

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Pepsinogens (PGA) are the inactive precursors of pepsin, the major acid protease found in the stomach. The PGA gene family exhibits polymorphic variation in human populations that can either be demonstrated by electrophoretic analysis of the proteins or by analysis of the respective genes with cDNA probes. Here, we describe the interrelationships between the most common pepsinogen protein phenotypes and the corresponding pepsinogen haplotypes (A, B, and C) containing different combinations of the PGA3, PGA4, and PGA5 genes. We propose that this unusual genetic variation involving haplotypes that contain three, two, and one genes, respectively, is the result of molecular evolution by gene duplication.

Original language	English (US)
Pages (from-to)	848-854
Number of pages	7
Journal	American journal of human genetics
Volume	38
Issue number	6
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "Relationships between the human pepsinogen DNA and protein polymorphisms",

abstract = "Pepsinogens (PGA) are the inactive precursors of pepsin, the major acid protease found in the stomach. The PGA gene family exhibits polymorphic variation in human populations that can either be demonstrated by electrophoretic analysis of the proteins or by analysis of the respective genes with cDNA probes. Here, we describe the interrelationships between the most common pepsinogen protein phenotypes and the corresponding pepsinogen haplotypes (A, B, and C) containing different combinations of the PGA3, PGA4, and PGA5 genes. We propose that this unusual genetic variation involving haplotypes that contain three, two, and one genes, respectively, is the result of molecular evolution by gene duplication.",

author = "Taggart, {R. T.} and Samloff, {I. M.} and Raffel, {L. J.} and A. Graham and C. Cass and Petersen, {G. M.} and Rotter, {J. I.} and Skolnick, {M. H.} and Schwartz, {C. E.} and Bell, {G. I.}",

year = "1986",

language = "English (US)",

volume = "38",

pages = "848--854",

journal = "American Journal of Human Genetics",

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TY - JOUR

T1 - Relationships between the human pepsinogen DNA and protein polymorphisms

AU - Taggart, R. T.

AU - Samloff, I. M.

AU - Raffel, L. J.

AU - Graham, A.

AU - Cass, C.

AU - Petersen, G. M.

AU - Rotter, J. I.

AU - Skolnick, M. H.

AU - Schwartz, C. E.

AU - Bell, G. I.

PY - 1986

Y1 - 1986

N2 - Pepsinogens (PGA) are the inactive precursors of pepsin, the major acid protease found in the stomach. The PGA gene family exhibits polymorphic variation in human populations that can either be demonstrated by electrophoretic analysis of the proteins or by analysis of the respective genes with cDNA probes. Here, we describe the interrelationships between the most common pepsinogen protein phenotypes and the corresponding pepsinogen haplotypes (A, B, and C) containing different combinations of the PGA3, PGA4, and PGA5 genes. We propose that this unusual genetic variation involving haplotypes that contain three, two, and one genes, respectively, is the result of molecular evolution by gene duplication.

AB - Pepsinogens (PGA) are the inactive precursors of pepsin, the major acid protease found in the stomach. The PGA gene family exhibits polymorphic variation in human populations that can either be demonstrated by electrophoretic analysis of the proteins or by analysis of the respective genes with cDNA probes. Here, we describe the interrelationships between the most common pepsinogen protein phenotypes and the corresponding pepsinogen haplotypes (A, B, and C) containing different combinations of the PGA3, PGA4, and PGA5 genes. We propose that this unusual genetic variation involving haplotypes that contain three, two, and one genes, respectively, is the result of molecular evolution by gene duplication.

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JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 6

ER -

Relationships between the human pepsinogen DNA and protein polymorphisms

Abstract

ASJC Scopus subject areas

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