Relationships between insulin sensitivity and measures of body fat in asymptomatic men and women

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To assess whether measures of body fat by DXA scanning can improve prediction of insulin sensitivity (SI) beyond what is possible with traditional measures, such as BMI, waist circumference, and waist-to-hip ratio (WHR). Research Methods and Procedures: Frequently sampled intravenous glucose tolerance tests were performed in 256 asymptomatic non-Hispanic white subjects from Rochester, MN (age 19-60 years; 123 men and 133 women) to determine the SI index by Bergman's minimal model technique. Height, weight, and waist and hip circumferences were measured for calculation of BMI and WHR; DXA was used to determine fat in the head, upper body, abdomen, and lower body. Linear regression was used to assess their relationships with SI after sex stratification and adjustment for age. Results: After controlling for age, increases in traditional and DXA measures of fat were consistently associated with smaller declines in SI among women than among men. In men, after controlling for age, all of the predictive information of SI was provided by waist circumference (additional R2+ 0.39, p< 0.001); none of the DXA measures improved the ability to predict SI. In women, after adjustment for age, BMI, and WHR, the only DXA measure that improved the prediction of SI was percentage head fat (additional R2+ 0.03, p< 0.001). Discussion: Equivalent increases in most measures of body fat had lesser impact on SI in women than in men. In both sexes, the predictive information provided by DXA measures is approximately equal to, but not additive to, that provided by simpler, traditional measures.

Original languageEnglish (US)
Pages (from-to)2070-2077
Number of pages8
JournalObesity Research
Volume12
Issue number12
DOIs
StatePublished - Dec 2004

Fingerprint

insulin resistance
body fat
Waist-Hip Ratio
Insulin Resistance
Adipose Tissue
Waist Circumference
waist-to-hip ratio
Fats
waist circumference
Head
lipids
Glucose Tolerance Test
prediction
Abdomen
waist
gender
Hip
Linear Models
research methods
hips

Keywords

  • Body fat
  • DXA
  • Insulin
  • Insulin sensitivity
  • Predictors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology
  • Public Health, Environmental and Occupational Health
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Relationships between insulin sensitivity and measures of body fat in asymptomatic men and women. / Sierra-Johnson, Justo; Johnson, Bruce David; Bailey, Kent R; Turner, Stephen T.

In: Obesity Research, Vol. 12, No. 12, 12.2004, p. 2070-2077.

Research output: Contribution to journalArticle

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