TY - JOUR
T1 - Relationships between C-reactive protein concentration and genotype in healthy volunteers
AU - Jones, Jennifer
AU - Chen, Li Sheng
AU - Baudhuin, Linnea
AU - Peterson, Sandra
AU - Harmsen, W. Scott
AU - Zinsmeister, Alan R.
AU - McConnell, Joseph
AU - Sandborn, William J.
N1 - Funding Information:
1)Grant support: This study was supported by a grant from Celltech (now UCB Pharma) and the Mayo Foundation for Medical Education and Research. Financial disclosures: Dr. Jones has served as a consultant for Schering-Plough and UCB Pharma and has received education support from Schering-Plough and Abbott. Dr. Sand-born has served as a consultant for and received research support from UCB Pharma and has participated in continuing medical education events indirectly supported by UCB Pharma. None of the other authors have any direct conflicts to disclose. *Corresponding author: William J. Sandborn, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA Phone: +1-507-284-0959, Fax: +1-507-266-0335, E-mail: sandborn.william@mayo.edu Received March 11, 2008; accepted September 7, 2008; previously published online December 10, 2008 Table 1 Clinical and demographic characteristics of the study population.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background: Polymorphisms of the gene for C-reactive protein (CRP) alter baseline serum CRP concentrations. The impact of polymorphisms of the CRP gene (genotype) on the normal range for CRP concentrations (phenotype) has not been determined. This study evaluated the median serum CRP concentrations in normal subjects stratified for CRP genotype, after adjustment for relevant covariates as well as polymorphisms in tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) genotypes. Methods: A total of 423 healthy adults without infectious or inflammatory conditions undergoing phlebotomy for laboratory testing were enrolled in the study. Assays for serum high sensitivity CRP (hs-CRP), IL-6, and TNF-α genotypes were measured. Results: The median hs-CRP concentration was 0.96 mg/L (range <0.1-40.15 mg/L). The CRP 1444 C/T heterozygote and homozygote genotype was associated with a significantly higher hs-CRP concentration (p<0.05), even after multivariate analysis controlling for age, gender, body mass index, hypertension, dyslipidemia and obstructive sleep apnea. The CRP 286 C/T/A heterozygote genotype was significant (p<0.05) in the multi-variable analysis, univariately was borderline significant (p=0.052). Conclusions: Selected genetic polymorphisms of the CRP gene are independently associated with higher basal hs-CRP concentrations in healthy adults. Larger studies are needed to perform haplotype analyses and to adequately evaluate the relationship between hs-CRP and genetic polymorphisms with lower allelic frequencies.
AB - Background: Polymorphisms of the gene for C-reactive protein (CRP) alter baseline serum CRP concentrations. The impact of polymorphisms of the CRP gene (genotype) on the normal range for CRP concentrations (phenotype) has not been determined. This study evaluated the median serum CRP concentrations in normal subjects stratified for CRP genotype, after adjustment for relevant covariates as well as polymorphisms in tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) genotypes. Methods: A total of 423 healthy adults without infectious or inflammatory conditions undergoing phlebotomy for laboratory testing were enrolled in the study. Assays for serum high sensitivity CRP (hs-CRP), IL-6, and TNF-α genotypes were measured. Results: The median hs-CRP concentration was 0.96 mg/L (range <0.1-40.15 mg/L). The CRP 1444 C/T heterozygote and homozygote genotype was associated with a significantly higher hs-CRP concentration (p<0.05), even after multivariate analysis controlling for age, gender, body mass index, hypertension, dyslipidemia and obstructive sleep apnea. The CRP 286 C/T/A heterozygote genotype was significant (p<0.05) in the multi-variable analysis, univariately was borderline significant (p=0.052). Conclusions: Selected genetic polymorphisms of the CRP gene are independently associated with higher basal hs-CRP concentrations in healthy adults. Larger studies are needed to perform haplotype analyses and to adequately evaluate the relationship between hs-CRP and genetic polymorphisms with lower allelic frequencies.
KW - Genotype
KW - High sensitivity C-reactive protein
KW - Phenotype
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U2 - 10.1515/CCLM.2009.005
DO - 10.1515/CCLM.2009.005
M3 - Article
C2 - 19072030
AN - SCOPUS:58149234042
SN - 1434-6621
VL - 47
SP - 20
EP - 25
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 1
ER -