Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function

Arthur Li, Abhiram Prasad, Rita Mincemoyer, Colleen Satorius, Neal Epstein, Toren Finkel, Arshed A. Quyyumi

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Patients with coronary artery disease (CAD) have impaired endothelial function in part due to an increase in vascular oxidant stress, p22phox, an essential component of the NADPH oxidase, is thought to play a critical role in the generation of superoxide anions in the vessel wall. The C242T polymorphism, located in the potential heme-binding site of the p22phox gene, has recently been reported to confer a protective effect on CAD risk in a Japanese study population. In a U.S. population of 252 patients (83% Caucasian) undergoing angiography for diagnosis of CAD, we investigated whether the C242T polymorphism was associated with the presence of CAD. In a subset of 142 patients, we studied whether the polymorphism manifests its potential protective effects through alteration of vascular endothelial function by measuring coronary epicardial and microvascular responses to intracoronary acetylcholine and sodium nitroprusside. Prevalence of the C242T allele was not different in 149 patients with CAD compared to 103 patients with angiographically normal coronary arteries (65.1% vs. 54.4%, P = 0.11). The C242T allele frequency in our population was nearly fourfold higher than reported previously in a Japanese population. There were also no significant differences in coronary epicardial or microvascular responses to acetylcholine or sodium nitroprusside between groups of patients with or without the C242T allele. In a U.S. population, the C242T polymorphism does not ap. pear to confer protection from endothelial dysfunction or CAD.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalAmerican journal of medical genetics
Volume86
Issue number1
DOIs
StatePublished - Aug 25 1999

Keywords

  • Coronary artery disease
  • Endothelium
  • Genes
  • Oxidant stress

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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